Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors

Carboxy-terminal telopeptide of type I collagen (ICTP) is generated through matrix metalloproteinase (MMP)-dependent type I collagen digestion, and has been widely utilized as a biomarker for bone turnover. The fact that atherosclerotic lesions are rich in both type I collagen and MMP-producing macr...

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Bibliographic Details
Published in:Endocrine Journal 2016, Vol.63(4), pp.397-404
Main Authors: Kondo, Takeshi, Endo, Itsuro, Aihara, Ken-ichi, Onishi, Yukiyo, Dong, Bingzi, Ohguro, Yukari, Kurahashi, Kiyoe, Yoshida, Sumiko, Fujinaka, Yuichi, Kuroda, Akio, Matsuhisa, Munehide, Fukumoto, Seiji, Matsumoto, Toshio, Abe, Masahiro
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Ankle Brachial Index
Atherosclerosis
baPWV
Cardiovascular Diseases - etiology
Cardiovascular Diseases - physiopathology
Carotid Artery Diseases - blood
Carotid Artery Diseases - physiopathology
Carotid Intima-Media Thickness
Collagen Type I - blood
Disease Progression
Female
Humans
ICTP
Male
Max IMT
Middle Aged
Peptides - blood
Pulse Wave Analysis
Risk Factors
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Summary:Carboxy-terminal telopeptide of type I collagen (ICTP) is generated through matrix metalloproteinase (MMP)-dependent type I collagen digestion, and has been widely utilized as a biomarker for bone turnover. The fact that atherosclerotic lesions are rich in both type I collagen and MMP-producing macrophages led to the hypothesis that serum ICTP concentrations may serve as a non-invasive clinical biomarker for atherosclerosis. Therefore, the association of serum ICTP concentrations with the maximum intima-media thickness (IMT) of carotid arteries, a surrogate index of systemic atherosclerosis, or brachial-ankle pulse wave velocity (baPWV) in patients with atherosclerotic risk factors was evaluated. A total of 52 male and 65 female (mean age: 62.8 yrs) patients without renal failure, malignancies or bone diseases known to affect serum ICTP concentrations were recruited. Patients with max IMTs ≥1.1 mm showed significantly higher serum ICTP concentrations compared with patients with max IMTs
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ15-0589