A clinicopathological study of peripheral lymph nodes in HIV-infected patients with special reference to CD4+ T-cell counts: Experience from a tertiary care institution in Darjeeling (India)

Background HIV/AIDS is a major health burden worldwide. India bears the third highest HIV‐patients load globally. In the Darjeeling district, HIV‐prevalence is >1% with very little known about the profile of HIV‐lymphadenopathy. The aim of this study was to identify the different causes of periph...

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Bibliographic Details
Published in:Diagnostic cytopathology 2015-12, Vol.43 (12), p.971-977
Main Authors: Mandal, Rupali, Mondal, Krishnendu, Datta, Saikat, Chakrabarti, Indranil, Giri, Amita, Goswami, Bidyut Krishna
Format: Article
Language:English
Subjects:
absolute lymphocyte count
AIDS-Related Complex - pathology
AIDS-Related Opportunistic Infections - pathology
CD4 Lymphocyte Count
CD4+ T-cell count
Female
FNAC
HIV
Human immunodeficiency virus
Humans
India
Lymph Nodes - pathology
Lymphatic Diseases - pathology
Male
Mycobacterium
Peripheral lymphadenopathy
Tertiary Care Centers
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Summary:Background HIV/AIDS is a major health burden worldwide. India bears the third highest HIV‐patients load globally. In the Darjeeling district, HIV‐prevalence is >1% with very little known about the profile of HIV‐lymphadenopathy. The aim of this study was to identify the different causes of peripheral lymphadenopathy among HIV–infected patients in this region, correlate them with CD4+ T‐cell counts and formulate some common clinico‐haematological parameters as potential predictors of CD4+ T‐cell count. Methods In the present study, 76 cases were evaluated. Fine Needle Aspiration Cytology (FNAC) was performed as an out‐patient procedure in the Department of Pathology. Smears were stained routinely with Haematoxylin‐Eosin and Leishman stains. ZN stains were done when indicated by the cytological findings. Immediate CD4+ T‐cell count was obtained by referring the patients to the Anti‐retroviral therapy centre. Results Cytological diagnoses included tuberculosis (82.9%), reactive hyperplasia (6.6%), nonspecific granulomatous lesions (3.9%), non‐Hodgkin lymphoma (2.6%), histoplasmosis (2.6%) and simultaneous filariasis with toxoplasmosis (1.3%). Statistically, the opportunistic infections and lymphomas significantly concurred with a CD4+ T‐cell count
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.23379