Female sex, central lymph node metastasis and dissection are causes of globus symptom after thyroidectomy

Globus symptoms are not uncommon after an uncomplicated thyroidectomy. However, their associated factors and etiology have not been investigated. We investigated the etiology and factors related to globus symptoms after thyroidectomy. The medical records of 289 patients who underwent thyroidectomy a...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2016-06, Vol.273 (6), p.1607-1613
Main Authors: Nam, Inn-Chul, Cho, Young-Jin, Bae, Ja-Sung, Lee, So-Hee, Park, Jun-Ook, Shim, Mi-Ran, Hwang, Yeon-Shin, Kim, Sang-Yeon, Joo, Young-Hoon, Sun, Dong-Il
Format: Article
Language:English
Subjects:
Adult
Aged
Dissection
Female
Foreign Bodies
Head and Neck
Head and Neck Surgery
Humans
Lymph Node Excision
Lymph Nodes - pathology
Lymphatic Metastasis
Male
Medicine
Medicine & Public Health
Middle Aged
Neck Dissection - methods
Neurosurgery
Otorhinolaryngology
Postoperative Complications
Sensation Disorders - etiology
Sex Factors
Surveys and Questionnaires
Thyroid Neoplasms - pathology
Thyroidectomy - adverse effects
Thyroidectomy - methods
Voice Disorders - etiology
Young Adult
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Summary:Globus symptoms are not uncommon after an uncomplicated thyroidectomy. However, their associated factors and etiology have not been investigated. We investigated the etiology and factors related to globus symptoms after thyroidectomy. The medical records of 289 patients who underwent thyroidectomy and completed a voice analysis, psychiatric screening, and voice-related questionnaires before and 1 month after the surgery were reviewed. Patients were excluded if they had globus symptoms before surgery or scored high on the psychiatric questionnaire. The selected patients were divided into two groups according to development of globus symptoms after surgery. Clinicopathological parameters and results of the voice analysis and voice-related questionnaires were compared between the two groups. A total of 157 patients were enrolled, and more than half (80/155, 51 %) showed development of globus symptoms 1 month after thyroidectomy. Female patients [hazard ratio (HR), 2.605; P  = 0.010], patients who had central lymph node metastasis (HR, 3.533; P  = 0.001), and patients who underwent central neck dissection (HR, 3.652; P  = 0.014) had a higher probability of developing globus symptoms. Patients who developed globus symptoms scored higher on the voice-related questionnaire, and had a greater decrease in speaking fundamental frequency ( P  
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-015-3676-8