Preserved Self-other Distinction During Empathy in Autism is Linked to Network Integrity of Right Supramarginal Gyrus

Autism spectrum disorder (ASD) shows deficits in self-other distinction during theory of mind (ToM). Here we investigated whether ASD patients also show difficulties in self-other distinction during empathy and if potential deficits are linked to dysfunctional resting-state connectivity patterns. In...

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Bibliographic Details
Published in:Journal of autism and developmental disorders 2016-02, Vol.46 (2), p.637-648
Main Authors: Hoffmann, Ferdinand, Koehne, Svenja, Steinbeis, Nikolaus, Dziobek, Isabel, Singer, Tania
Format: Article
Language:English
Subjects:
Adult
Affect
Affective Behavior
Autism
Autistic children
Autistic Disorder - physiopathology
Autistic Disorder - psychology
Behavioral Science and Psychology
Bias
Brain
Brain Hemisphere Functions
Care and treatment
Case-Control Studies
Child and School Psychology
Cognition
Cognition & reasoning
Cognitive Ability
Complications and side effects
Control Groups
Discourse
Dysfunctional
Emotions
Empathy
Experimental Groups
Female
Functional magnetic resonance imaging
Humans
Individualized Instruction
Integrity
Interpersonal relations
Magnetic Resonance Imaging
Male
Meta Analysis
Middle Aged
Morality
Negative Attitudes
Neuropsychology
Neurosciences
Original Paper
Parietal Lobe - physiology
Pediatrics
Personality
Pervasive Developmental Disorders
Psychology
Public Health
Resting
Self Concept
Singers
Theory of Mind
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Summary:Autism spectrum disorder (ASD) shows deficits in self-other distinction during theory of mind (ToM). Here we investigated whether ASD patients also show difficulties in self-other distinction during empathy and if potential deficits are linked to dysfunctional resting-state connectivity patterns. In a first study, ASD patients and controls performed an emotional egocentricity paradigm and a ToM task. In the second study, resting-state connectivity of right temporo-parietal junction and right supramarginal gyrus (rSMG) were analysed using a large-scale fMRI data set. ASD patients exhibited deficient ToM but normal emotional egocentricity, which was paralleled by reduced connectivity of regions of the ToM network and unimpaired rSMG network connectivity. These results suggest spared self-other distinction during empathy and an intact rSMG network in ASD.
ISSN:0162-3257
1573-3432
DOI:10.1007/s10803-015-2609-0