Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol

Many spices, including plants of the ginger family, possess anticarcinogenic activity. However, the molecular mechanisms by which they exert their antitumorigenic effects are unknown. Activator protein 1 (AP-1) has a critical role in tumor promotion, and blocking of tumor promoter-induced activation...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2001-02, Vol.61 (3), p.850-853
Main Authors: Bode, A M, Ma, W Y, Surh, Y J, Dong, Z
Format: Article
Language:English
Subjects:
Animals
Anticarcinogenic Agents - pharmacology
Catechols
Cell Death - drug effects
Cell Line
Cell Transformation, Neoplastic - chemically induced
Cell Transformation, Neoplastic - drug effects
DNA - metabolism
Enzyme Induction - drug effects
Epidermal Growth Factor - antagonists & inhibitors
Epidermis - cytology
Epidermis - drug effects
Fatty Alcohols - pharmacology
gingerol
Guaiacol - analogs & derivatives
Guaiacol - pharmacology
Ketones - pharmacology
Mice
Mitogen-Activated Protein Kinases - metabolism
p38 Mitogen-Activated Protein Kinases
paradol
Phosphorylation - drug effects
Plants, Medicinal
Transcription Factor AP-1 - metabolism
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Summary:Many spices, including plants of the ginger family, possess anticarcinogenic activity. However, the molecular mechanisms by which they exert their antitumorigenic effects are unknown. Activator protein 1 (AP-1) has a critical role in tumor promotion, and blocking of tumor promoter-induced activation of AP-1 inhibits neoplastic transformation. Epidermal growth factor induces cell transformation and AP-1 activity. The purpose of this study was to investigate the effect of two structurally related compounds of the ginger family, [6]-gingerol and [6]-paradol, on EGF-induced cell transformation and AP-1 activation. Our results provide the first evidence that both block EGF-induced cell transformation but act by different mechanisms.
ISSN:0008-5472