Altered frontal pole development affects self-generated spatial working memory in ADHD

• Published in: Brain & development (Tokyo. 1979) 2016-05, Vol.38 (5), p.471-480
• Main Authors: Arai, Sumiyoshi, Okamoto, Yuko, Fujioka, Toru, Inohara, Keisuke, Ishitobi, Makoto, Matsumura, Yukiko, Jung, Minyoung, Kawamura, Kaori, Takiguchi, Shinichiro, Tomoda, Akemi, Wada, Yuji, Hiratani, Michio, Matsuura, Naomi, Kosaka, Hirotaka
• Format: Article
• Language: English
• Subjects: Attention Deficit Disorder with Hyperactivity - physiopathology; Attention deficit hyperactivity disorder (ADHD); Brain Mapping - methods; Cambridge Automated Neuropsychological Battery (CANTAB®); Case-Control Studies; Child; Development; Female; Frontal Lobe - physiopathology; Humans; Male; Memory, Short-Term - physiology; Near-infrared spectroscopy (NIRS); Neurology; Neuropsychological Tests; Prefrontal cortex (PFC); Prefrontal Cortex - metabolism; Self-generated spatial working memory (SWM); Spatial Navigation - physiology; Spectroscopy, Near-Infrared - methods
• ISSN: 0387-7604; 1872-7131
• DOI: 10.1016/j.braindev.2015.11.005

Abstract Background Spatial working memory (SWM) dysfunction is a feature of attention deficit hyperactivity disorder (ADHD). Previous studies suggested that behavioral performance in self-generated SWM improves through development in children with and without ADHD. Nevertheless, developmental changes in the neural underpinnings of self-generated SWM are unknown. Method Using near-infrared spectroscopy, hemodynamic activity in the prefrontal cortex (PFC) was measured in 30 children with ADHD (9.5 ± 1.6 years-old) and 35 TD children (9.0 ± 1.6 years-old) while they performed a self-generated SWM task. We then investigated correlations between age and behavioral performance, and between age and hemodynamic activity in the PFC for each group. Results Both groups showed a negative correlation with age and number of errors [ADHD: r (28) = −0.37, p = 0.040; TD: r (33) = −0.59, p < 0.001], indicating that self-generated SWM improves through development. The TD group showed a positive correlation between age and oxygenated hemoglobin in the frontal pole [10ch: r (33) = 0.41, p = 0.013; 11ch; r (33) = 0.44, p = 0.008] and bilateral lateral PFC [4ch: r (33) = 0.34, p = 0.049; 13ch; r (33) = 0.54, p = 0.001], while no significant correlation was found in the ADHD group. Furthermore, regression slopes for the frontal pole significantly differed between the TD and ADHD groups [10ch: t (61) = 2.35, p = 0.021; 11ch: t (61) = 2.05, p = 0.044]. Conclusion Children with ADHD showed abnormalities in functional maturation of the frontal pole, which plays a role in manipulating and maintaining information associated with self-generated behavior.