Phaeohyphomycosis in transplant recipients: Results from the Transplant Associated Infection Surveillance Network (TRANSNET)

Transplant recipients are at a high risk for developing invasive fungal infections. The agents of phaeohyphomycosis are environmental molds found worldwide, and they cause a broad spectrum of disease including skin and subcutaneous lesions, pneumonia, central nervous system disease, fungemia, and di...

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Bibliographic Details
Published in:Medical mycology (Oxford) 2015-06, Vol.53 (5), p.440-446
Main Authors: McCarty, Todd P., Baddley, John W., Walsh, Thomas J., Alexander, Barbara D., Kontoyiannis, Dimitrios P., Perl, Trish M., Walker, Randall, Patterson, Thomas F., Schuster, Mindy G., Lyon, G. Marshall, Wingard, John R., Andes, David R., Park, Benjamin J., Brandt, Mary E., Pappas, Peter G.
Format: Article
Language:English
Subjects:
Adult
Aged
Alternaria
Antifungal Agents - therapeutic use
Epidemiological Monitoring
Female
Humans
Male
Middle Aged
Opportunistic Infections - drug therapy
Opportunistic Infections - epidemiology
Opportunistic Infections - mortality
Opportunistic Infections - pathology
Phaeohyphomycosis - drug therapy
Phaeohyphomycosis - epidemiology
Phaeohyphomycosis - mortality
Phaeohyphomycosis - pathology
Prospective Studies
Survival Analysis
Transplant Recipients
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Summary:Transplant recipients are at a high risk for developing invasive fungal infections. The agents of phaeohyphomycosis are environmental molds found worldwide, and they cause a broad spectrum of disease including skin and subcutaneous lesions, pneumonia, central nervous system disease, fungemia, and disseminated disease. Using data from the Transplant Associated Infection Surveillance Network (TRANSNET), we evaluated patients with proven and probable phaeohyphomycosis. Centers collected data on demographics, co-morbid conditions, clinical features, treatment, and three-month mortality. Fifty-six patients with phaeohyphomycosis were identified from 15 centers, comprising 26 stem cell transplant (SCT) and 30 solid organ transplant (SOT) recipients. Median time to diagnosis post-transplant was 358 days (SCT 100 days; SOT 685 days; P =
ISSN:1369-3786
1460-2709
DOI:10.1093/mmy/myv018