Protective Effects of Aspirin and Vitamin E (α-Tocopherol) against Copper- and Cadmium-Induced Toxicity

A 24-h exposure to copper (400 μM, 600 μM) or cadmium (5 μM, 10 μM) significantly reduces the viability of COS-7 cells. A 2-h preincubation with vitamin E does not protect COS-7 cells from copper-induced toxicity, but does protect against cadmium-induced toxicity. Preincubation with aspirin protects...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2001-07, Vol.285 (4), p.921-925
Main Authors: Mattie, Michael D., Freedman, Jonathan H.
Format: Article
Language:English
Subjects:
Animals
antioxidant
Antioxidants - pharmacology
aspirin
Aspirin - pharmacology
cadmium
Cadmium - toxicity
copper
Copper - toxicity
COS Cells
COS-7 cells
Dose-Response Relationship, Drug
Protective Agents - pharmacology
Toxicity Tests
vitamin E
Vitamin E - pharmacology
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Summary:A 24-h exposure to copper (400 μM, 600 μM) or cadmium (5 μM, 10 μM) significantly reduces the viability of COS-7 cells. A 2-h preincubation with vitamin E does not protect COS-7 cells from copper-induced toxicity, but does protect against cadmium-induced toxicity. Preincubation with aspirin protects cells from both copper- and cadmium-induced toxicity. A combination of aspirin and vitamin E (10 μM and 25 μM, respectively) increases cell viability in copper-exposed cells in a clearly additive manner, while in cadmium-exposed cells the effects are slightly additive. These results indicate that aspirin and vitamin E can protect cells from metal-induced toxicity. Differences in the protective effects of aspirin and vitamin E on copper versus cadmium-induced toxicity may be due to alternative mechanisms of metal toxicity or antioxidant activity.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.2001.5259