Synthesis and Biologically Important of 2-Mercaptobenthiazole (MBT)-Clubbed Chalcone Derivatives

In this present work base catalyzed method used for formation of Chalcone of(E)-4-(3-(4-hydroxyphenyl)acryloyl)-5-methyl-2(p-tolyl)-1H-pyraz o l-3(2H)-one (II) reacted with derivatives of S-benzo[d]thiol-2yl-2-chloroethanethioate (I sub( a-f)) resulted in formation of corresponding derivatives of (E...

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Bibliographic Details
Published in:International letters of chemistry, physics and astronomy physics and astronomy, 2016-01, Vol.63, p.83-83
Main Authors: Bhabhor, Falguni, Satish, K, Variya, Hiren, Panchal, Vikram
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Astronomy
Bacteria
Derivatives
Formations
Infrared radiation
Spectra
Synthesis
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Summary:In this present work base catalyzed method used for formation of Chalcone of(E)-4-(3-(4-hydroxyphenyl)acryloyl)-5-methyl-2(p-tolyl)-1H-pyraz o l-3(2H)-one (II) reacted with derivatives of S-benzo[d]thiol-2yl-2-chloroethanethioate (I sub( a-f)) resulted in formation of corresponding derivatives of (E)-S-benzo[d]thiazol-2-yl 2-(4-(3-(5-methyl-3oxo-2(p-tolyl)-2,3-dihydro-1H-pyrazol-4-yl)-3-o x oprop-1-en-1-yl)phenoxy)etanethioate(III sub( a-f)) was confirmed by spectral characterization such as IR, 1H NMR, LC-MS and elemental analysis. The compounds were screened for their antimicrobial properties against a broad panel Gram-positive and Gram-negative bacteria as well as fungi.
ISSN:2299-3843
2299-3843
DOI:10.18052/www.scipress.com/ILCPA.63.83