Development of a human physiologically based pharmacokinetic (PBPK) model for dermal permeability for lindane

•Two estimation methods are compared for dermal skin patch data parameters.•Incorporating molecular weight improves dermal permeability fits.•Protein binding is essential for prediction of steady-state permeability. Lindane is a neurotoxicant used for the treatment of lice and scabies present on hum...

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Bibliographic Details
Published in:Toxicology letters 2016-03, Vol.245, p.106-109
Main Authors: Sawyer, Megan E., Evans, Marina V., Wilson, Charles A., Beesley, Lauren J., Leon, Lider S., Eklund, Chris R., Croom, Edward L., Pegram, Rex A.
Format: Article
Language:English
Subjects:
Algorithms
Binding
Dermal absorption
Dermal permeability
Diffusion
Human
Humans
In vivo methods and tests
Insecticides - pharmacokinetics
Lindane
Lindane - pharmacokinetics
Lipid Metabolism
Mathematical models
Models, Biological
PBPK
Permeability
Protein Binding
Skin - metabolism
Skin Absorption
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Summary:•Two estimation methods are compared for dermal skin patch data parameters.•Incorporating molecular weight improves dermal permeability fits.•Protein binding is essential for prediction of steady-state permeability. Lindane is a neurotoxicant used for the treatment of lice and scabies present on human skin. Due to its pharmaceutical application, an extensive pharmacokinetic database exists in humans. Mathematical diffusion models allow for calculation of lindane skin permeability coefficients using human kinetic data obtained from in vitro and in vivo experimentation as well as a default compound-specific calculation based on physicochemical characteristics used in the absence of kinetic data. A dermal model was developed to describe lindane diffusion into the skin, where the skin compartment consisted of homogeneous dermal tissue. This study utilized Fick's law of diffusion along with chemical binding to protein and lipids to determine appropriate dermal absorption parameters which were then incorporated into a physiologically based pharmacokinetic (PBPK) model to describe in vivo kinetics. The estimation of permeability coefficients using chemical binding in combination with in vivo data demonstrates the advantages of combining physiochemical properties with a PBPK model to predict dermal absorption.
ISSN:0378-4274
1879-3169
DOI:10.1016/j.toxlet.2016.01.008