A robust super-tough biodegradable elastomer engineered by supramolecular ionic interactions

Abstract Alginate-based supramolecular ionic polyurethanes (ASPUs) as mechanically tunable biomaterials with high strength and toughness in both dry and hydrated states are developed under metal-free conditions. The Young's modulus and tensile strength of ASPUs are tuned from 30 to 100 MPa, and...

Full description

Saved in:
Bibliographic Details
Published in:Biomaterials 2016-04, Vol.84, p.54-63
Main Authors: Daemi, Hamed, Rajabi-Zeleti, Sareh, Sardon, Haritz, Barikani, Mehdi, Khademhosseini, Ali, Baharvand, Hossein
Format: Article
Language:English
Subjects:
Advanced Basic Science
Alginate
Alginates - chemical synthesis
Alginates - chemistry
Animals
Biocompatible Materials - pharmacology
Biodegradability
Biodegradation
Biomaterials
Biomedical materials
Dentistry
Elastomers
Elastomers - chemical synthesis
Elastomers - chemistry
Elastomers - pharmacology
Glucuronic Acid - chemical synthesis
Glucuronic Acid - chemistry
Hexuronic Acids - chemical synthesis
Hexuronic Acids - chemistry
Human Umbilical Vein Endothelial Cells - drug effects
Humans
Ionic interactions
Ions - chemistry
Load-bearing tissue
Male
Materials Testing - methods
Polyurethane resins
Polyurethanes - chemical synthesis
Polyurethanes - chemistry
Rats, Wistar
Self-healing
Supramolecular elastomer
Surgical implants
Tensile strength
Vascular tissue engineering
Weight-Bearing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Alginate-based supramolecular ionic polyurethanes (ASPUs) as mechanically tunable biomaterials with high strength and toughness in both dry and hydrated states are developed under metal-free conditions. The Young's modulus and tensile strength of ASPUs are tuned from 30 to 100 MPa, and 20 to 50 MPa, respectively. Interestingly, the ASPUs exhibit a small hysteresis loop, minimal loss of tensile strength and minimal creep deformation after 100 repetitive cycles which makes them of use for engineering of load-bearing tissues. This is the first report that describes a linear PU can resist a large number of cyclic stresses without significant stretching. These bio-based elastomers engineered by ionic interactions are biocompatible and biodegradable. The ASPUs demonstrate a similar in vivo degradation rate compared to polycaprolactone (PCL). These biomaterials also demonstrate a rapid self-healing and recovery after rupture, and have a linear biodegradation profile. Furthermore, histological examination of subcutaneous transplanted ASPUs after five months reveals low immunological response and low fibrosis.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2016.01.025