Neutrophil gelatinase‐associated lipocalin in dogs with chronic kidney disease, carcinoma, lymphoma and endotoxaemia

• Published in: Journal of small animal practice 2016-06, Vol.57 (6), p.291-298
• Main Authors: Cobrin, A. R., Blois, S. L., Abrams-Ogg, A. C. G., Kruth, S. A., Dewey, C., Holowaychuk, M. K., Gauthier, V.
• Format: Article
• Language: English
• Subjects: Animals; Carcinoma - metabolism; Carcinoma - veterinary; Creatinine - metabolism; Dog Diseases - metabolism; Dogs; Endotoxemia - metabolism; Endotoxemia - veterinary; Lipocalin-2 - metabolism; Lymphoma - metabolism; Lymphoma - veterinary; Prospective Studies; Reference Values; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - veterinary
• ISSN: 0022-4510; 1748-5827
• DOI: 10.1111/jsap.12481

OBJECTIVES: To measure serum and urine neutrophil gelatinase‐associated lipocalin (NGAL) concentrations in healthy dogs and dogs with chronic kidney disease, neoplasia and endotoxaemia. METHODS: Serum and urine NGAL concentrations were measured in 42 healthy dogs, 11 dogs with chronic kidney disease, 12 dogs with carcinoma, 20 dogs with lymphoma and 15 dogs with lipopolysaccharide‐induced endotoxaemia. In dogs with chronic kidney disease, NGAL was measured 3 and 6 months later. RESULTS: Compared with healthy controls, dogs with chronic kidney disease (PÄ0·0008), carcinoma (PÄ0·0072) and lymphoma (PÄ0·0008) had elevated serum and urine NGAL and urine NGAL‐to‐creatinine ratio. Serum and urine NGAL was not significantly different between dogs with chronic kidney disease, carcinoma or lymphoma (Pê0·12). In dogs with non‐progressive chronic kidney disease, NGAL concentrations did not change significantly over the 6‐month study period. CLINICAL SIGNIFICANCE: NGAL can be elevated by chronic kidney disease and neoplasia, compared with healthy controls. Further research is needed to determine if uNGAL or uNGAL‐to‐creatinine ratio is more specific than serum levels to detect chronic kidney disease.