Head and neck second primary cancer rates in the human papillomavirus era: A population-based analysis

Background Patients with head and neck cancer are at high risk for second primary malignancies. Human papillomavirus (HPV)‐driven tumors are generally high‐grade oropharyngeal cancers. We analyzed the incidence of second primary malignancy of the head and neck in patients with primary squamous cell...

Full description

Saved in:
Bibliographic Details
Published in:Head & neck 2016-04, Vol.38 (S1), p.E873-E883
Main Authors: Diaz, Dayssy Alexandra, Reis, Isildinha M., Weed, Donald T., Elsayyad, Nagy, Samuels, Michael, Abramowitz, Matthew C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
and End Results (SEER)
Carcinoma, Squamous Cell - epidemiology
Carcinoma, Squamous Cell - virology
Epidemiology
Female
head and neck cancer
Head and Neck Neoplasms - epidemiology
Head and Neck Neoplasms - virology
Human papillomavirus
human papillomavirus (HPV)
Humans
Incidence
Male
Middle Aged
Neoplasms, Second Primary - epidemiology
Neoplasms, Second Primary - virology
oropharyngeal cancer
Oropharyngeal Neoplasms - epidemiology
Oropharyngeal Neoplasms - virology
Papillomaviridae
Papillomavirus Infections - complications
second cancers
SEER Program
Surveillance
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Patients with head and neck cancer are at high risk for second primary malignancies. Human papillomavirus (HPV)‐driven tumors are generally high‐grade oropharyngeal cancers. We analyzed the incidence of second primary malignancy of the head and neck in patients with primary squamous cell carcinoma (SCC) of the head and neck and temporal trends in the HPV era. Methods The Surveillance, Epidemiology, and End Results (SEER) database was queried for patients with SCC of the head and neck (range, 1973–2008). Cumulative incidence rates of second primary malignancy of the head and neck were compared based on competing risk analysis. Results A total of 104,639 cases were included in this study, of which 4616 patients had second primary malignancy of the head and neck. Oropharyngeal cancer incidence increased over time. Estimated incidence rate/10,000 person‐years (105.5, 80.6, and 50.2 for 1973–1989, 1990–1999, and 2000–2008, respectively) and cumulative incidence rates (10‐year rates of 6.68%, 5.72%, and 4.59% for 1973–1989, 1990–1999, and 2000–2008, respectively) of second primary malignancies of the head and neck for patients with oropharyngeal cancer decreased over time (p 
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.24119