Preventing ventriculostomy-related infections with antibiotic-impregnated drains in hospitals: a two-centre Dutch study

Summary This observational cohort study assessed the effect of the introduction of antibiotic-impregnated external ventricular drains (AI-EVDs), as opposed to plain silicone EVDs, on the occurrence of ventriculostomy-related infections (VRIs) in two Dutch hospitals, with no other changes to their cl...

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Bibliographic Details
Published in:The Journal of hospital infection 2016-04, Vol.92 (4), p.401-404
Main Authors: Verberk, J.D.M, Berkelbach van der Sprenkel, J.W, Arts, M.P, Dennesen, P.J.W, Bonten, M.J.M, van Mourik, M.S.M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - therapeutic use
Antibiotic-impregnated
Cohort Studies
Competing risks
Drainage - methods
External ventricular drains
Female
Hospitals
Humans
Infectious Disease
Male
Middle Aged
Netherlands
Neurosurgery
Surgical Wound Infection - epidemiology
Surgical Wound Infection - prevention & control
Survival
Treatment Outcome
Ventriculostomy - adverse effects
Ventriculostomy-related infection
Young Adult
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Summary:Summary This observational cohort study assessed the effect of the introduction of antibiotic-impregnated external ventricular drains (AI-EVDs), as opposed to plain silicone EVDs, on the occurrence of ventriculostomy-related infections (VRIs) in two Dutch hospitals, with no other changes to their clinical practice. VRI was defined using the criteria of the Centers for Disease Control and Prevention, and with a culture-based definition. A propensity-score-adjusted competing risks survival analysis showed that introduction of AI-EVDs did not significantly decrease the risk of VRIs in routine care, nor affect the bacterial aetiology, even after adjustment for confounding and competing events.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2015.12.018