Factors associated with the failure of Intermittent Preventive Treatment for malaria among pregnant women in Yaounde

• Published in: The Pan African medical journal 2016, Vol.23, p.152-152
• Main Authors: Essiben, Félix, Foumane, Pascal, de Nguefack, Marcelle Aurelie Tsafack, Eko, Filbert Eko, Njotang, Philip Nana, Enow, Robinson Mbu, Mboudou, Emile Telesphore
• Format: Article
• Language: eng ; fre
• Subjects: Adult; Antimalarials - administration & dosage; Antimalarials - therapeutic use; Cameroon - epidemiology; Case-Control Studies; Drug Combinations; Female; Hospitalization - statistics & numerical data; Humans; Logistic Models; Malaria - epidemiology; Malaria - prevention & control; Pregnancy; Pregnancy Complications, Parasitic - epidemiology; Pregnancy Complications, Parasitic - prevention & control; Pyrimethamine - administration & dosage; Pyrimethamine - therapeutic use; Risk Factors; Sulfadoxine - administration & dosage; Sulfadoxine - therapeutic use; Treatment Failure; Young Adult
• ISSN: 1937-8688
• DOI: 10.11604/pamj.2016.23.152.7936

Intermittent preventive treatment with sulfadoxine-pyrimethamine (IPTp-SP) is recommended for malaria prevention during pregnancy. We investigated factors associated with the failure of this strategy. We conducted a case-control study in two health care facilities in Yaounde, from 1 May 2014 to 30 April 2015. Pregnant women treated with IPTp-SP, hospitalized for malaria and having a positive Rapid Diagnostic Test (RDT) result (case-subjects) were compared to pregnant women treated with IPTp-SP having a negative RDT result (control-subjects). Epi Info 7 software and SPSS 18.0 software were used with P< 0.05 as significance threshold. We recruited 234 subjects, 109 (46.6%) case-subjects and 125 control-subjects (53.4%). The associated factors found were: prematurity (P=0.03; OR=1.15; IC= 0.32 - 4.10), the non-use of LLIN (P=0.006; OR= 2.31; IC= 1.26 - 4.25), a history of hospitalization for malaria (P=0.007; OR= 2.19; IC= 1.23 - 3.89), IPTp-SP administration after 28 gestational weeks (P=0.001, OR= 3.55; IC= 1.7 - 7.61). After logistic regression, prematurity (P=0.024; OR=2.01; IC=1.1-3.7) and a history of hospitalization for malaria (P=0.001; OR=2.83; IC=1.50-5.4) remained associated with IPTp-SP failure. A history of hospitalization for malaria and prematurity are independent predictor of IPTp-SP failure.