Ductal adenoma of breast: imaging characteristics and radiologic–pathologic correlation of unique findings which reflect “pseudoinvasion”

Purpose To investigate the imaging characteristics of rare ductal adenoma of the breast, we evaluated the detailed imaging findings and correlated them with the pathologic features of the ductal adenomas. In particular, we describe in detail the imaging findings derived from “pseudoinvasion,” one of...

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Bibliographic Details
Published in:Breast cancer (Tokyo, Japan) Japan), 2016-07, Vol.23 (4), p.597-606
Main Authors: Matsubayashi, Roka Namoto, Momosaki, Seiya, Muranaka, Toru
Format: Article
Language:English
Subjects:
Adenoma
Adenoma - diagnostic imaging
Adenoma - pathology
Adenoma - surgery
Aged
Aged, 80 and over
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
Breast Neoplasms - surgery
Cancer Research
Contrast Media
Diagnostic imaging
Female
Humans
Magnetic Resonance Imaging - methods
Mammography - methods
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Oncology
Original Article
Surgery
Surgical Oncology
Ultrasonography, Mammary - methods
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Summary:Purpose To investigate the imaging characteristics of rare ductal adenoma of the breast, we evaluated the detailed imaging findings and correlated them with the pathologic features of the ductal adenomas. In particular, we describe in detail the imaging findings derived from “pseudoinvasion,” one of the histological features unique to this tumor. Materials and methods We reviewed the imaging findings including magnetic resonance imaging (MRI) in three patients with ductal adenomas of the breast and correlated the findings with the detailed histological features. Results All patients exhibited well-demarcated nodules with smooth margins on mammography. On ultrasonography, two patients exhibited mural nodules within cysts. The bases of mural nodules protruded into the mammary glands. On contrast-enhanced MRI, these margins were smooth. Histologically, the bases showed foci of tumor cells scattered into collagenous materials (pseudoinvasion), the tumor foci were located along the collagen fibers; therefore, the margins were smooth. Conclusions Distinguishing ductal adenoma from invasive carcinoma is an urgent issue. A clear margin of ‘pseudoinvasion’ on MRI is both a unique finding and a useful diagnostic clue.
ISSN:1340-6868
1880-4233
DOI:10.1007/s12282-015-0608-9