Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N‑Aryl Glycine Esters with Terminal Alkynes

A copper-catalyzed enantioselective cross-coupling of a Csp3–H moiety (N-aryl glycine ester) with a Csp–H component (terminal alkyne) using molecular oxygen as the terminal oxidant is described for the first time. The sustainable method provides an efficient and environmentally friendly approach to...

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Bibliographic Details
Published in:Organic letters 2016-06, Vol.18 (12), p.2982-2985
Main Authors: Xie, Zhiyu, Liu, Xigong, Liu, Lei
Format: Article
Language:English
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Summary:A copper-catalyzed enantioselective cross-coupling of a Csp3–H moiety (N-aryl glycine ester) with a Csp–H component (terminal alkyne) using molecular oxygen as the terminal oxidant is described for the first time. The sustainable method provides an efficient and environmentally friendly approach to rapidly prepare a diverse array of optically active non-natural α-amino acids.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b01328