Vitamin D Supplementation for Premenstrual Syndrome-Related Mood Disorders in Adolescents with Severe Hypovitaminosis D

Abstract Study Objective Premenstrual syndrome (PMS) might become severe enough to interfere with normal interpersonal relationships. This study was planned to assess whether administration of vitamin D (200,000 IU at first, followed by 25,000 IU every 2 weeks) for a 4-month period might lessen the...

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Bibliographic Details
Published in:Journal of pediatric & adolescent gynecology 2016-08, Vol.29 (4), p.357-361
Main Authors: Tartagni, Massimo, MD, Cicinelli, Maria Vittoria, MD, Tartagni, Mario Valerio, MD, Alrasheed, Hala, MD, Matteo, Maria, MD, Baldini, Domenico, MD, De Salvia, Maria, PhD, Loverro, Giuseppe, MD, Montagnani, Monica, MD, PhD
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
Dietary Supplements
Drug Administration Schedule
Female
Humans
Mood disorders
Mood Disorders - blood
Mood Disorders - etiology
Mood Disorders - therapy
Obstetrics and Gynecology
Pediatrics
Premenstrual Dysphoric Disorder - blood
Premenstrual Dysphoric Disorder - therapy
Premenstrual syndrome (PMS)
Premenstrual Syndrome - blood
Premenstrual Syndrome - psychology
Premenstrual Syndrome - therapy
Vitamin D
Vitamin D - administration & dosage
Vitamin D - blood
Vitamin D Deficiency - psychology
Vitamin D Deficiency - therapy
Vitamins - administration & dosage
Young Adult
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Summary:Abstract Study Objective Premenstrual syndrome (PMS) might become severe enough to interfere with normal interpersonal relationships. This study was planned to assess whether administration of vitamin D (200,000 IU at first, followed by 25,000 IU every 2 weeks) for a 4-month period might lessen the appearance and the intensity of mood disorders associated with PMS in young girls with severe hypovitaminosis D. Design, Setting, Participants, Interventions, and Main Outcome Measures One hundred fifty-eight young girls (15-21 years old) with PMS-related severe symptoms of the emotional and cognitive domains and low serum 25-hydroxycholecalciferol (25-OH-D) levels (≤10 ng/mL) were randomly assigned to two treatment groups and treated for 4 months with vitamin D (group 1; n = 80) or placebo (group 2; n = 78). Clinical and hormonal effects were compared between the two groups. Results In patients from group 1, levels of vitamin D reached the normal range (35-60 ng/mL) after the first month and remained stable throughout the whole study. At the end of treatment, anxiety score decreased from 51 to 20 ( P  
ISSN:1083-3188
1873-4332
DOI:10.1016/j.jpag.2015.12.006