Chitosan Electrodeposition for Microrobotic Drug Delivery

A method to functionalize steerable magnetic microdevices through the co‐electrodeposition of drug loaded chitosan hydrogels is presented. The characteristics of the polymer matrix have been investigated in terms of fabrication, morphology, drug release and response to different environmental condit...

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Bibliographic Details
Published in:Advanced healthcare materials 2013-07, Vol.2 (7), p.1037-1044
Main Authors: Fusco, Stefano, Chatzipirpiridis, George, Sivaraman, Kartik M., Ergeneman, Olgaç, Nelson, Bradley J., Pané, Salvador
Format: Article
Language:English
Subjects:
Chitosan
Chitosan - chemistry
drug delivery
Drug Delivery Systems
Drugs
Electrochemical Techniques
electrodeposition
Eyes
Hydrogels
Immersion coating
microrobotics
Microrobots
Microscopy, Electron, Scanning
Robotics
smart materials
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Summary:A method to functionalize steerable magnetic microdevices through the co‐electrodeposition of drug loaded chitosan hydrogels is presented. The characteristics of the polymer matrix have been investigated in terms of fabrication, morphology, drug release and response to different environmental conditions. Modifications of the matrix behavior could be achieved by simple chemical post processing. The system is able to load and deliver 40–80 μg cm−2 of a model drug (Brilliant Green) in a sustained manner with different profiles. Chitosan allows a pH responsive behavior with faster and more efficient release under slightly acidic conditions as can be present in tumor or inflamed tissue. A prototype of a microrobot functionalized with the hydrogel is presented and proposed for the treatment of posterior eye diseases. Chitosan drug loaded matrices are electrodeposited on conductive surfaces and modified by simple dip coating processes with an ionic crosslinker solution. Drug release is evaluated in different pH conditions mimicking possible changes due to local inflammation or disease. The method is intended to functionalize capsules for drug delivery into the eye.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201200409