Diffusion and Birefringence of Bioactive Dyes in a Supramolecular Guanosine Hydrogel

Transparent self‐standing supramolecular hydrogels were readily prepared by the potassium‐ion‐mediated self‐organization of guanosine and 8‐bromoguanosine whilst the individual components precipitated within a few hours. VT‐NMR spectroscopy showed that bromoguanosine was a superior gelator compared...

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Bibliographic Details
Published in:Chemistry : a European journal 2012-05, Vol.18 (19), p.6008-6014
Main Authors: Das, Rabindra Nath, Kumar, Y. Pavan, Pagoti, Sreenivasarao, Patil, Avinash J., Dash, Jyotirmayee
Format: Article
Language:English
Subjects:
Biocompatibility
Birefringence
Chemistry
Coloring Agents - chemistry
Diffusion
Dyes
dyes/pigments
Guanosine - analogs & derivatives
Guanosine - chemical synthesis
Guanosine - chemistry
Guanosines
Hydrogels
Hydrogels - chemistry
Microscopy, Atomic Force
Microscopy, Confocal
Molecular Structure
Networks
nucleosides
Potassium - chemistry
self-assembly
Spectrometry, Fluorescence
Spectroscopy
Spectrum analysis
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Summary:Transparent self‐standing supramolecular hydrogels were readily prepared by the potassium‐ion‐mediated self‐organization of guanosine and 8‐bromoguanosine whilst the individual components precipitated within a few hours. VT‐NMR spectroscopy showed that bromoguanosine was a superior gelator compared to guanosine. XRD analysis showed that gel formation was caused by stacked G‐quartets. AFM analysis revealed dendritic architectures of the nanofibers in the two‐component hydrogel network. DSC profiles showed that the hybrid hydrogels underwent sol–gel transition at lower temperature than the pure guanosine and bromoguanosine hydrogels. Interestingly, bioactive dyes, such as rose bengal, rhodamine‐6‐G, and fluorescein, could be diffused and released in a controlled manner. UV/Vis absorption and fluorescence spectroscopy and CLSM were used to investigate the diffusion behavior of dyes in the hydrogel network. These dyes exhibited strong birefringence in the gel network (0.07–0.1) as a result of the anisotropic organization. Old before I dye: The K+‐ion‐mediated self‐association of two simple nucleoside building blocks, guanosine and bromoguanosine, produced transparent self‐standing supramolecular hydrogels with dendritic nanoarchitectures (see figure) that diffused and released bioactive small molecules and exhibited strong birefringence in the presence of dyes.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201103814