The Mechanism by which a Peptide Based on Complementarity-Determining Region-1 of a Pathogenic Anti-DNA Auto-Ab Ameliorates Experimental Systemic Lupus Erythematosus

A peptide based on complementarity-determining region (CDR)-1 of a monoclonal murine anti-DNA Ab that bears the common idiotype, 16/6Id, was synthesized and characterized. The peptide, designated pCDR1, was found to be an immunodominant T-cell epitope in BALB/c mice. The CDR1-based peptide was shown...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS 2001-01, Vol.98 (3), p.1148-1153
Main Authors:	Eilat, Eran, Dayan, Molly, Zinger, Heidy, Mozes, Edna
Format:	Article
Language:	English
Subjects:	Amino Acid Sequence Animals Antibodies, Antinuclear - blood Antibodies, Antinuclear - chemistry Antibodies, Antinuclear - immunology Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - immunology Biological Sciences Cells, Cultured complementarity-determining region 1 Cytokines Cytokines - biosynthesis Deoxyribonucleic acid Disease Disease manifestations Disease Models, Animal DNA Drug Administration Schedule Enzyme-Linked Immunosorbent Assay Epitopes - immunology Humans Immunoglobulin Fragments - administration & dosage Immunoglobulin Fragments - chemistry Immunoglobulin Fragments - therapeutic use Immunology Inductive reasoning Injections, Intravenous Injections, Subcutaneous Kidneys Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Lupus Erythematosus, Systemic - prevention & control Lymphocytes - immunology Mice Mice, Inbred BALB C Molecular Sequence Data Peptides Preventive medicine Proteinuria Rodents Secretion Spleen - immunology Systemic lupus erythematosus T lymphocytes T-Lymphocytes - immunology
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