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Decrease of microscopic Plasmodium falciparum infection prevalence during pregnancy following IPTp-SP implementation in urban cities of Gabon
Background Six years after the implementation of intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) in Gabon, its impact on placental malaria and pregnancy outcomes remains unknown. Methods Age, gestational data, use of IPTp-SP and birth weight were recorded du...
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| Published in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 2016-06, Vol.110 (6), p.333-342 |
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| creator | Bouyou-Akotet, M.K. Mawili-Mboumba, D.P. Kendjo, E. Moutandou Chiesa, S. Tshibola Mbuyi, M.L. Tsoumbou-Bakana, G. Zong, J. Ambounda, N. Kombila, M. |
| description | Background
Six years after the implementation of intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) in Gabon, its impact on placental malaria and pregnancy outcomes remains unknown.
Methods
Age, gestational data, use of IPTp-SP and birth weight were recorded during a hospital-based cross-sectional survey performed in 2011 in 387 women at the end of pregnancy.
Results
Malaria prevalence was 6.7 and 5.3% in peripheral and placental blood respectively. Overall, 59.0% women took at least two IPTp-SP doses which was associated with 50% reduction of Plasmodium; (P.) falciparum infection in primigravidae. Previous malaria treatment was a risk factor for peripheral P. falciparum infection, while uptake of IPTp-SP was associated with reduced parasitaemia. Anaemia prevalence was 38.0%, low birth weight and prematurity rates were 6.0 and 12.0% respectively. Young age was associated with a higher frequency of malaria, anaemia, low birth weight and preterm delivery (p |
| doi_str_mv | 10.1093/trstmh/trw034 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1801433003</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/trstmh/trw034</oup_id><sourcerecordid>1801433003</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-e834482b4d15acb96438252a8e642f19c5b81b1e4f9de64de78e927291655c823</originalsourceid><addsrcrecordid>eNqFUctOwzAQtBAISuHIFfnIJeBHnDpHVKBUQqIS5Rw5zqYYxXawExAfwT-TUB5HTrsazc5oZxA6oeSckpxfdCF29mkYb4SnO2hC5UwmXBC-iyaEcJHkjPADdBjjMyFMUJHvowM2Y5mcUT5BH1egA6gI2NfYGh181L41Gq8aFa2vTG9xrRptWhWG1bgadGe8w22AV9WA04CrPhi3GZGNU06_49o3jX8bseVq3SYPK2xs24AF16mvY-NwH0rlsDadgTh6L1Tp3RHaG8wiHH_PKXq8uV7Pb5O7-8VyfnmXaM6yLgHJ01SyMq2oULrMs5RLJpiSkKWsprkWpaQlhbTOqwGqYCYhH37OaSaEloxP0dlWtw3-pYfYFdZEDU2jHPg-FlQSmnI-5DdQky11jCYGqIs2GKvCe0FJMTZQbBsotg0M_NNv6b60UP2yfyL_8_Z9-4_WJ2dElLw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1801433003</pqid></control><display><type>article</type><title>Decrease of microscopic Plasmodium falciparum infection prevalence during pregnancy following IPTp-SP implementation in urban cities of Gabon</title><source>Oxford Journals Online</source><creator>Bouyou-Akotet, M.K. ; Mawili-Mboumba, D.P. ; Kendjo, E. ; Moutandou Chiesa, S. ; Tshibola Mbuyi, M.L. ; Tsoumbou-Bakana, G. ; Zong, J. ; Ambounda, N. ; Kombila, M.</creator><creatorcontrib>Bouyou-Akotet, M.K. ; Mawili-Mboumba, D.P. ; Kendjo, E. ; Moutandou Chiesa, S. ; Tshibola Mbuyi, M.L. ; Tsoumbou-Bakana, G. ; Zong, J. ; Ambounda, N. ; Kombila, M.</creatorcontrib><description>Background
Six years after the implementation of intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) in Gabon, its impact on placental malaria and pregnancy outcomes remains unknown.
Methods
Age, gestational data, use of IPTp-SP and birth weight were recorded during a hospital-based cross-sectional survey performed in 2011 in 387 women at the end of pregnancy.
Results
Malaria prevalence was 6.7 and 5.3% in peripheral and placental blood respectively. Overall, 59.0% women took at least two IPTp-SP doses which was associated with 50% reduction of Plasmodium; (P.) falciparum infection in primigravidae. Previous malaria treatment was a risk factor for peripheral P. falciparum infection, while uptake of IPTp-SP was associated with reduced parasitaemia. Anaemia prevalence was 38.0%, low birth weight and prematurity rates were 6.0 and 12.0% respectively. Young age was associated with a higher frequency of malaria, anaemia, low birth weight and preterm delivery (p<0.01). Birth weight significantly rose with increasing age (p<0.01), parity (p=0.03) and number of SP doses (p=0.03). A birth weight reduction of 230 g in case of peripheral parasitaemia (p=0.02) and of 210 g with placental parasitaemia (p=0.13) was observed.
Conclusions
Microscopic P. falciparum prevalence during pregnancy significantly declined between 2005 and 2011, following IPTp-SP implementation in Gabon. Young women and paucigravidae remain the most susceptible to malaria and associated outcomes.</description><identifier>ISSN: 0035-9203</identifier><identifier>EISSN: 1878-3503</identifier><identifier>DOI: 10.1093/trstmh/trw034</identifier><identifier>PMID: 27268713</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject><![CDATA[Adult ; Anemia - complications ; Anemia - epidemiology ; Antimalarials - administration & dosage ; Antimalarials - therapeutic use ; Birth Weight ; Cities ; Cross-Sectional Studies ; Drug Combinations ; Female ; Gabon ; Gravidity ; Humans ; Infant, Low Birth Weight ; Infant, Newborn ; Infant, Premature ; Malaria, Falciparum - epidemiology ; Malaria, Falciparum - parasitology ; Malaria, Falciparum - prevention & control ; Parasitemia - epidemiology ; Parasitemia - parasitology ; Parasitemia - prevention & control ; Placenta ; Plasmodium falciparum ; Pregnancy ; Pregnancy Complications, Parasitic - epidemiology ; Pregnancy Complications, Parasitic - parasitology ; Pregnancy Complications, Parasitic - prevention & control ; Pregnancy Outcome ; Prevalence ; Pyrimethamine - administration & dosage ; Pyrimethamine - therapeutic use ; Sulfadoxine - administration & dosage ; Sulfadoxine - therapeutic use ; Urban Population ; Young Adult]]></subject><ispartof>Transactions of the Royal Society of Tropical Medicine and Hygiene, 2016-06, Vol.110 (6), p.333-342</ispartof><rights>The Author 2016. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2016</rights><rights>The Author 2016. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-e834482b4d15acb96438252a8e642f19c5b81b1e4f9de64de78e927291655c823</citedby><cites>FETCH-LOGICAL-c326t-e834482b4d15acb96438252a8e642f19c5b81b1e4f9de64de78e927291655c823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27268713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouyou-Akotet, M.K.</creatorcontrib><creatorcontrib>Mawili-Mboumba, D.P.</creatorcontrib><creatorcontrib>Kendjo, E.</creatorcontrib><creatorcontrib>Moutandou Chiesa, S.</creatorcontrib><creatorcontrib>Tshibola Mbuyi, M.L.</creatorcontrib><creatorcontrib>Tsoumbou-Bakana, G.</creatorcontrib><creatorcontrib>Zong, J.</creatorcontrib><creatorcontrib>Ambounda, N.</creatorcontrib><creatorcontrib>Kombila, M.</creatorcontrib><title>Decrease of microscopic Plasmodium falciparum infection prevalence during pregnancy following IPTp-SP implementation in urban cities of Gabon</title><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><addtitle>Trans R Soc Trop Med Hyg</addtitle><description>Background
Six years after the implementation of intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) in Gabon, its impact on placental malaria and pregnancy outcomes remains unknown.
Methods
Age, gestational data, use of IPTp-SP and birth weight were recorded during a hospital-based cross-sectional survey performed in 2011 in 387 women at the end of pregnancy.
Results
Malaria prevalence was 6.7 and 5.3% in peripheral and placental blood respectively. Overall, 59.0% women took at least two IPTp-SP doses which was associated with 50% reduction of Plasmodium; (P.) falciparum infection in primigravidae. Previous malaria treatment was a risk factor for peripheral P. falciparum infection, while uptake of IPTp-SP was associated with reduced parasitaemia. Anaemia prevalence was 38.0%, low birth weight and prematurity rates were 6.0 and 12.0% respectively. Young age was associated with a higher frequency of malaria, anaemia, low birth weight and preterm delivery (p<0.01). Birth weight significantly rose with increasing age (p<0.01), parity (p=0.03) and number of SP doses (p=0.03). A birth weight reduction of 230 g in case of peripheral parasitaemia (p=0.02) and of 210 g with placental parasitaemia (p=0.13) was observed.
Conclusions
Microscopic P. falciparum prevalence during pregnancy significantly declined between 2005 and 2011, following IPTp-SP implementation in Gabon. Young women and paucigravidae remain the most susceptible to malaria and associated outcomes.</description><subject>Adult</subject><subject>Anemia - complications</subject><subject>Anemia - epidemiology</subject><subject>Antimalarials - administration & dosage</subject><subject>Antimalarials - therapeutic use</subject><subject>Birth Weight</subject><subject>Cities</subject><subject>Cross-Sectional Studies</subject><subject>Drug Combinations</subject><subject>Female</subject><subject>Gabon</subject><subject>Gravidity</subject><subject>Humans</subject><subject>Infant, Low Birth Weight</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Malaria, Falciparum - epidemiology</subject><subject>Malaria, Falciparum - parasitology</subject><subject>Malaria, Falciparum - prevention & control</subject><subject>Parasitemia - epidemiology</subject><subject>Parasitemia - parasitology</subject><subject>Parasitemia - prevention & control</subject><subject>Placenta</subject><subject>Plasmodium falciparum</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Parasitic - epidemiology</subject><subject>Pregnancy Complications, Parasitic - parasitology</subject><subject>Pregnancy Complications, Parasitic - prevention & control</subject><subject>Pregnancy Outcome</subject><subject>Prevalence</subject><subject>Pyrimethamine - administration & dosage</subject><subject>Pyrimethamine - therapeutic use</subject><subject>Sulfadoxine - administration & dosage</subject><subject>Sulfadoxine - therapeutic use</subject><subject>Urban Population</subject><subject>Young Adult</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqFUctOwzAQtBAISuHIFfnIJeBHnDpHVKBUQqIS5Rw5zqYYxXawExAfwT-TUB5HTrsazc5oZxA6oeSckpxfdCF29mkYb4SnO2hC5UwmXBC-iyaEcJHkjPADdBjjMyFMUJHvowM2Y5mcUT5BH1egA6gI2NfYGh181L41Gq8aFa2vTG9xrRptWhWG1bgadGe8w22AV9WA04CrPhi3GZGNU06_49o3jX8bseVq3SYPK2xs24AF16mvY-NwH0rlsDadgTh6L1Tp3RHaG8wiHH_PKXq8uV7Pb5O7-8VyfnmXaM6yLgHJ01SyMq2oULrMs5RLJpiSkKWsprkWpaQlhbTOqwGqYCYhH37OaSaEloxP0dlWtw3-pYfYFdZEDU2jHPg-FlQSmnI-5DdQky11jCYGqIs2GKvCe0FJMTZQbBsotg0M_NNv6b60UP2yfyL_8_Z9-4_WJ2dElLw</recordid><startdate>201606</startdate><enddate>201606</enddate><creator>Bouyou-Akotet, M.K.</creator><creator>Mawili-Mboumba, D.P.</creator><creator>Kendjo, E.</creator><creator>Moutandou Chiesa, S.</creator><creator>Tshibola Mbuyi, M.L.</creator><creator>Tsoumbou-Bakana, G.</creator><creator>Zong, J.</creator><creator>Ambounda, N.</creator><creator>Kombila, M.</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201606</creationdate><title>Decrease of microscopic Plasmodium falciparum infection prevalence during pregnancy following IPTp-SP implementation in urban cities of Gabon</title><author>Bouyou-Akotet, M.K. ; Mawili-Mboumba, D.P. ; Kendjo, E. ; Moutandou Chiesa, S. ; Tshibola Mbuyi, M.L. ; Tsoumbou-Bakana, G. ; Zong, J. ; Ambounda, N. ; Kombila, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-e834482b4d15acb96438252a8e642f19c5b81b1e4f9de64de78e927291655c823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Anemia - complications</topic><topic>Anemia - epidemiology</topic><topic>Antimalarials - administration & dosage</topic><topic>Antimalarials - therapeutic use</topic><topic>Birth Weight</topic><topic>Cities</topic><topic>Cross-Sectional Studies</topic><topic>Drug Combinations</topic><topic>Female</topic><topic>Gabon</topic><topic>Gravidity</topic><topic>Humans</topic><topic>Infant, Low Birth Weight</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Malaria, Falciparum - epidemiology</topic><topic>Malaria, Falciparum - parasitology</topic><topic>Malaria, Falciparum - prevention & control</topic><topic>Parasitemia - epidemiology</topic><topic>Parasitemia - parasitology</topic><topic>Parasitemia - prevention & control</topic><topic>Placenta</topic><topic>Plasmodium falciparum</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Parasitic - epidemiology</topic><topic>Pregnancy Complications, Parasitic - parasitology</topic><topic>Pregnancy Complications, Parasitic - prevention & control</topic><topic>Pregnancy Outcome</topic><topic>Prevalence</topic><topic>Pyrimethamine - administration & dosage</topic><topic>Pyrimethamine - therapeutic use</topic><topic>Sulfadoxine - administration & dosage</topic><topic>Sulfadoxine - therapeutic use</topic><topic>Urban Population</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouyou-Akotet, M.K.</creatorcontrib><creatorcontrib>Mawili-Mboumba, D.P.</creatorcontrib><creatorcontrib>Kendjo, E.</creatorcontrib><creatorcontrib>Moutandou Chiesa, S.</creatorcontrib><creatorcontrib>Tshibola Mbuyi, M.L.</creatorcontrib><creatorcontrib>Tsoumbou-Bakana, G.</creatorcontrib><creatorcontrib>Zong, J.</creatorcontrib><creatorcontrib>Ambounda, N.</creatorcontrib><creatorcontrib>Kombila, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouyou-Akotet, M.K.</au><au>Mawili-Mboumba, D.P.</au><au>Kendjo, E.</au><au>Moutandou Chiesa, S.</au><au>Tshibola Mbuyi, M.L.</au><au>Tsoumbou-Bakana, G.</au><au>Zong, J.</au><au>Ambounda, N.</au><au>Kombila, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decrease of microscopic Plasmodium falciparum infection prevalence during pregnancy following IPTp-SP implementation in urban cities of Gabon</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>2016-06</date><risdate>2016</risdate><volume>110</volume><issue>6</issue><spage>333</spage><epage>342</epage><pages>333-342</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><abstract>Background
Six years after the implementation of intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) in Gabon, its impact on placental malaria and pregnancy outcomes remains unknown.
Methods
Age, gestational data, use of IPTp-SP and birth weight were recorded during a hospital-based cross-sectional survey performed in 2011 in 387 women at the end of pregnancy.
Results
Malaria prevalence was 6.7 and 5.3% in peripheral and placental blood respectively. Overall, 59.0% women took at least two IPTp-SP doses which was associated with 50% reduction of Plasmodium; (P.) falciparum infection in primigravidae. Previous malaria treatment was a risk factor for peripheral P. falciparum infection, while uptake of IPTp-SP was associated with reduced parasitaemia. Anaemia prevalence was 38.0%, low birth weight and prematurity rates were 6.0 and 12.0% respectively. Young age was associated with a higher frequency of malaria, anaemia, low birth weight and preterm delivery (p<0.01). Birth weight significantly rose with increasing age (p<0.01), parity (p=0.03) and number of SP doses (p=0.03). A birth weight reduction of 230 g in case of peripheral parasitaemia (p=0.02) and of 210 g with placental parasitaemia (p=0.13) was observed.
Conclusions
Microscopic P. falciparum prevalence during pregnancy significantly declined between 2005 and 2011, following IPTp-SP implementation in Gabon. Young women and paucigravidae remain the most susceptible to malaria and associated outcomes.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>27268713</pmid><doi>10.1093/trstmh/trw034</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Anemia - complications Anemia - epidemiology Antimalarials - administration & dosage Antimalarials - therapeutic use Birth Weight Cities Cross-Sectional Studies Drug Combinations Female Gabon Gravidity Humans Infant, Low Birth Weight Infant, Newborn Infant, Premature Malaria, Falciparum - epidemiology Malaria, Falciparum - parasitology Malaria, Falciparum - prevention & control Parasitemia - epidemiology Parasitemia - parasitology Parasitemia - prevention & control Placenta Plasmodium falciparum Pregnancy Pregnancy Complications, Parasitic - epidemiology Pregnancy Complications, Parasitic - parasitology Pregnancy Complications, Parasitic - prevention & control Pregnancy Outcome Prevalence Pyrimethamine - administration & dosage Pyrimethamine - therapeutic use Sulfadoxine - administration & dosage Sulfadoxine - therapeutic use Urban Population Young Adult |
| title | Decrease of microscopic Plasmodium falciparum infection prevalence during pregnancy following IPTp-SP implementation in urban cities of Gabon |
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