Association between abdominal fat distribution, adipocytokines and metabolic alterations in obese low-birth-weight children

Summary Background In addition to obesity, low birth weight (LBW) has been proposed as another independent risk factor associated with cardiovascular disease and type 2 diabetes mellitus. Objective This study aimed to evaluate the influence of birth weight on abdominal fat distribution, adipocytokin...

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Bibliographic Details
Published in:Pediatric obesity 2016-08, Vol.11 (4), p.285-291
Main Authors: Domínguez Hernández, C., Klünder Klünder, M., Huang, F., Flores Armas, E. M., Velázquez-López, L., Medina-Bravo, P.
Format: Article
Language:English
Subjects:
Abdomen
abdominal adipose tissue
Abdominal Fat - metabolism
adipocytokines
Adipokines - blood
Birth Weight
Blood Glucose - analysis
Body Mass Index
Child
childhood obesity
Childrens health
Cross-Sectional Studies
Female
fetal programming
Health risk assessment
Humans
Infant, Low Birth Weight - metabolism
Insulin
Insulin - blood
Insulin Resistance
Lipids - blood
Male
Metabolism
Molecular weight
Obesity
Pediatric Obesity - metabolism
Pediatrics
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Summary:Summary Background In addition to obesity, low birth weight (LBW) has been proposed as another independent risk factor associated with cardiovascular disease and type 2 diabetes mellitus. Objective This study aimed to evaluate the influence of birth weight on abdominal fat distribution, adipocytokine levels and associated metabolic alterations in obese children. Methods A cross‐sectional study was conducted in 92 children. Children were divided into three groups according to their body mass index and birth weight. Glucose and insulin (0 and 120 min), lipid profile and adipocytokines were measured. Abdominal fat distribution was assessed by magnetic resonance imaging. Results Obese LBW children had higher fasting glucose (P = 0.054) and insulin (P 
ISSN:2047-6302
2047-6310
DOI:10.1111/ijpo.12060