Q fever and pregnancy: experience from the Limoges Regional University Hospital

Introduction Q fever is an ubiquitous zoonosis caused by Coxiella burnetii . Its tropism for the uterus is a potential source of obstetric complications. Materials and methods We describe the obstetric consequences of Q fever diagnosed during pregnancy from a series of cases. When an antenatal diagn...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2016-08, Vol.294 (2), p.233-238
Main Authors: Coste Mazeau, Perrine, Hantz, Sébastien, Eyraud, Jean-Luc, Donadel, Lorène, Lacorre, Aymeline, Rogez, Sylvie, Aubard, Yves, Gauthier, Tristan
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - therapeutic use
Antibiotics
Chronic Disease
Coxiella burnetii - isolation & purification
Endocrinology
Female
Fetal Death - etiology
Fetal Growth Retardation - etiology
Gynecology
Health risk assessment
Hospitals, University
Human Genetics
Humans
Maternal-Fetal Medicine
Medicine
Medicine & Public Health
Obstetric Labor, Premature - etiology
Obstetrics
Obstetrics/Perinatology/Midwifery
Placenta - pathology
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - epidemiology
Prenatal Diagnosis
Prevalence
Q Fever - complications
Q Fever - epidemiology
Retrospective Studies
Young Adult
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Summary:Introduction Q fever is an ubiquitous zoonosis caused by Coxiella burnetii . Its tropism for the uterus is a potential source of obstetric complications. Materials and methods We describe the obstetric consequences of Q fever diagnosed during pregnancy from a series of cases. When an antenatal diagnosis was made, antibiotic therapy with roxithromycin (Rulid ® ) was started until delivery. Results Between 2007 and 2012, 30 patients were treated for Q fever diagnosed during pregnancy, i.e. 1.9 cases per 1000 people. The most common reasons for performing serology was intrauterine growth retardation, preterm labor and oligoamnios. Q fever was diagnosed as acute and chronic in 26 and 4 cases, respectively. Progression to chronic disease occurred in 8 % of acute forms of the diseases. The prevalence of obstetric complications was 66 %, including 10 % foetal deaths, 31 % preterm delivery and 27 % low birthweight 
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-015-3958-9