Use of auditory brainstem responses for the early detection of ototoxicity from aminoglycosides or chemotherapeutic drugs

Effective objective HF (high-frequency) testing methodology provides for the early detection of ototoxic hearing loss because it typically progresses from high to low frequencies. Such early detection is considered necessary to prevent hearing loss from progressing into the frequency range important...

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Bibliographic Details
Published in:Journal of rehabilitation research and development 2004-05, Vol.41 (3A), p.373-382
Main Authors: Mitchell, Curtin R, Ellingson, Roger M, Henry, James A, Fausti, Stephen A
Format: Article
Language:English
Subjects:
Adult
Aminoglycosides - adverse effects
Antineoplastic Agents - adverse effects
Audiometry, Evoked Response - methods
Audiometry, Pure-Tone - methods
Auditory Threshold - physiology
Chemotherapy
Drugs
Early Diagnosis
Evoked Potentials, Auditory, Brain Stem - physiology
Female
Hearing loss
Hearing Loss, High-Frequency - chemically induced
Hearing Loss, High-Frequency - diagnosis
Humans
Male
Monitoring systems
R&D
Rehabilitation
Reproducibility of Results
Research & development
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Summary:Effective objective HF (high-frequency) testing methodology provides for the early detection of ototoxic hearing loss because it typically progresses from high to low frequencies. Such early detection is considered necessary to prevent hearing loss from progressing into the frequency range important for understanding speech. Objective tests must be reliable, sensitive to hearing change, and time efficient. Auditory brainstem responses (ABRs) appear well suited to this task; however, current ABR techniques have limitations. Conventional clicks stimulate middle (1-4 kHz) rather than high frequencies (>8 kHz). Responses to HF tone bursts require considerable recording time. We hypothesized that using HF band-limited clicks (HF clicks) could overcome these limitations. Two different HF clicks, with bandwidths of 8-14 kHz were used to elicit ABRs. The current study compared responses among these stimuli. The results demonstrate the reliability of HF-click responses and of tone bursts presented in trains.
ISSN:0748-7711
1938-1352
DOI:10.1682/JRRD.2003.05.0089