Increase in primary surgical treatment of T1 and T2 oropharyngeal squamous cell carcinoma and rates of adverse pathologic features: National Cancer Data Base

BACKGROUND There has been increasing interest in the primary surgical treatment of patients with early T classification (T1‐T2) oropharyngeal squamous cell carcinoma (OPSCC), with the stated goal of de‐escalating or avoiding adjuvant treatment. Herein, the authors sought to determine the degree to w...

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Bibliographic Details
Published in:Cancer 2016-05, Vol.122 (10), p.1523-1532
Main Authors: Cracchiolo, Jennifer R., Baxi, Shrujal S., Morris, Luc G., Ganly, Ian, Patel, Snehal G., Cohen, Marc A., Roman, Benjamin R.
Format: Article
Language:English
Subjects:
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Cohort Studies
extracapsular spread (ECS)
Female
Head and Neck Neoplasms - pathology
Head and Neck Neoplasms - surgery
human papillomavirus‐related oropharyngeal squamous cell carcinoma (OPSCC)
Humans
Male
Middle Aged
Neck Dissection - methods
Neck Dissection - statistics & numerical data
Neoplasm Staging
Oropharyngeal Neoplasms - pathology
Oropharyngeal Neoplasms - surgery
positive surgical margins
Practice Patterns, Physicians
Registries
Squamous Cell Carcinoma of Head and Neck
transoral robotic surgery (TORS)
Treatment Outcome
treatment selection
United States
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Summary:BACKGROUND There has been increasing interest in the primary surgical treatment of patients with early T classification (T1‐T2) oropharyngeal squamous cell carcinoma (OPSCC), with the stated goal of de‐escalating or avoiding adjuvant treatment. Herein, the authors sought to determine the degree to which this interest has translated into changes in practice patterns, and the rates of adverse postoperative pathologic features. METHODS Patients with T1 to T2 OPSCC in the National Cancer Data Base who were treated from 2004 through 2013 were categorized as receiving primary surgical or primary radiation‐based treatment. Trends in treatment selection and factors related to the selection of primary surgery were examined. The rates of adverse pathologic features including positive surgical margins, extracapsular spread (ECS), and advanced T and N classifications after surgery were analyzed. RESULTS Of 8768 patients with T1 to T2 OPSCC, 68% underwent primary surgical treatment, increasing from 56% in 2004 to 82% in 2013 (P
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.29938