Hybrid intensity-modulated radiation therapy (IMRT) simultaneous integrated boost (SIB) technique versus three-dimensional (3D) conformal radiotherapy with SIB for breast radiotherapy: a planning comparison

Aim This study aims to compare conventional simultaneous integrated boost (SIB) planning technique with a hybrid SIB intensity-modulated radiation therapy (IMRT) technique with varying open tangent to IMRT field dose ratios. Furthermore, we investigated which of the dose ratios proves the most favou...

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Published in:Journal of radiotherapy in practice 2016-06, Vol.15 (2), p.131-142
Main Authors: Smith, Shayne K., Estoesta, Reuben P., Kader, Jaraad A., Martin, Darren, Claridge-Mackonis, Elizabeth R., Toohey, Joanne M., Carroll, Susan L.
Format: Article
Language:English
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Summary:Aim This study aims to compare conventional simultaneous integrated boost (SIB) planning technique with a hybrid SIB intensity-modulated radiation therapy (IMRT) technique with varying open tangent to IMRT field dose ratios. Furthermore, we investigated which of the dose ratios proves the most favourable as a class solution across a sample. Methods In total, 15 patients with conventional SIB treatment plans were re-planned with hybrid SIB IMRT technique using three differing open field:IMRT dose ratios, that is, 80:20, 70:30 and 60:40. Plans were compared using dosimetric comparison of organs at risk (OARs) and homogeneity and conformity indexes across target structures. Results All hybrid plans reduced dose maximums and showed a reduction of high doses to both lungs but increased lower doses, that is, [ARMENIAN SMALL LETTER ECH], with similar results discovered for the heart. Contralateral breast dose was shown to decrease [ARMENIAN SMALL LETTER ECH] and V1 measures by hybrid arms, whereas increasing the V2. Left anterior descending artery dose and non-irradiated structures were reduced by all hybrid arms. The homogeneity and conformity increased across all hybrid arms. Qualitative assessment of all plans also favoured hybrid plans. Findings Hybrid plans produced superior dose conformity, homogeneity, reduced dose maximums and showed an improvement in most OAR parameters. The 70:30 hybrid technique exhibited greater benefits as a class solution to the sample than conventional plans due to superior dose conformity and homogeneity to target volumes.
ISSN:1460-3969
1467-1131
DOI:10.1017/S146039691600008X