Transthoracic Computed Tomography–Guided Lung Nodule Biopsy: Comparison of Core Needle and Fine Needle Aspiration Techniques

Abstract Purpose To determine if there is a statistically significant difference in the computed tomography (CT)–guided trans-thoracic needle biopsy diagnostic rate, complication rate, and degree of pathologist confidence in diagnosis between core needle biopsy (CNB) and fine needle aspiration biops...

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Bibliographic Details
Published in:Canadian Association of Radiologists journal 2016-08, Vol.67 (3), p.284-289
Main Authors: Sangha, Bippan S., MD, Hague, Cameron J., MD, Jessup, Jennifer, MD, O'Connor, Robert, MB, Mayo, John R., MD
Format: Article
Language:English
Subjects:
Aged
Attitude of Health Personnel
Biopsy
Biopsy, Fine-Needle - adverse effects
Biopsy, Large-Core Needle - adverse effects
Chest Tubes
Comparative analysis
Core needle biopsy
False Positive Reactions
Female
Fine needle aspiration biopsy
Hemoptysis - etiology
Humans
Hypodermic needles
Image-Guided Biopsy - adverse effects
Image-Guided Biopsy - methods
Length of Stay
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - pathology
Lung nodule
Lungs
Male
Medical imaging
Middle Aged
Pneumothorax - etiology
Radiology
Retrospective Studies
Sensitivity and Specificity
Tomography, X-Ray Computed
Transthoracic lung nodule biopsy
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Summary:Abstract Purpose To determine if there is a statistically significant difference in the computed tomography (CT)–guided trans-thoracic needle biopsy diagnostic rate, complication rate, and degree of pathologist confidence in diagnosis between core needle biopsy (CNB) and fine needle aspiration biopsy (FNAB). Methods A retrospective cohort design was used to compare the diagnostic biopsy rate, diagnostic confidence, and biopsy-related complications of pneumothorax, chest tube placement, pulmonary hemorrhage, hemoptysis, admission to hospital, and length of stay between 251 transthoracic needle biopsies obtained via CNB (126) or FNAB (125). Complication rates were assessed using imaging and clinical follow-up. Final diagnosis was confirmed via surgical pathology or clinical follow-up over a period of up to 10 years. Results CNB provided diagnostic samples in 91% and FNA in 80% of biopsies, which was statistically significant ( P  
ISSN:0846-5371
1488-2361
DOI:10.1016/j.carj.2015.10.005