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Prospective Comparison of Blood Culture Bottles and Conventional Swabs for Microbial Identification of Suspected Periprosthetic Joint Infection
Abstract Background Early, accurate detection of infection is vital to successful treatment of periprosthetic joint infection (PJI). Currently, no “gold standard” diagnostic testing exists. The goal of this prospective study was to compare the efficacy of a blood culture bottle system (BCBS) to comm...
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| Published in: | The Journal of arthroplasty 2016-08, Vol.31 (8), p.1779-1783 |
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| container_end_page | 1783 |
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| container_title | The Journal of arthroplasty |
| container_volume | 31 |
| creator | Geller, Jeffrey A., MD MacCallum, Katherine P., MD Murtagh, Taylor S., BS Patrick, David A., BS Liabaud, Barthelemy, MD Jonna, Venkata K., MD |
| description | Abstract Background Early, accurate detection of infection is vital to successful treatment of periprosthetic joint infection (PJI). Currently, no “gold standard” diagnostic testing exists. The goal of this prospective study was to compare the efficacy of a blood culture bottle system (BCBS) to commonly used culture swabs in confirming PJI in patients with high clinical suspicion. Methods Patients were selected for enrollment based on Musculoskeletal Infection Society guidelines for PJI. ESR and CRP were obtained prior to aspiration. Aspirated fluid was divided between BCBS, swab, and synovial fluid analysis. Forty-nine samples were analyzed. Results BCBS yielded 41 positive cultures versus 19 with swab (p |
| doi_str_mv | 10.1016/j.arth.2016.02.014 |
| format | article |
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Currently, no “gold standard” diagnostic testing exists. The goal of this prospective study was to compare the efficacy of a blood culture bottle system (BCBS) to commonly used culture swabs in confirming PJI in patients with high clinical suspicion. Methods Patients were selected for enrollment based on Musculoskeletal Infection Society guidelines for PJI. ESR and CRP were obtained prior to aspiration. Aspirated fluid was divided between BCBS, swab, and synovial fluid analysis. Forty-nine samples were analyzed. Results BCBS yielded 41 positive cultures versus 19 with swab (p<0.0001), particularly with respect to S. epidermidis . There were no false positive results in the BCBS group, using strict Musculoskeletal Infection Society guidelines. Conclusion BCBS increased identification of pathogens in lower extremity PJI, providing clinicians with a low-cost, broadly-applicable test.</description><identifier>ISSN: 0883-5403</identifier><identifier>EISSN: 1532-8406</identifier><identifier>DOI: 10.1016/j.arth.2016.02.014</identifier><identifier>PMID: 27020677</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Arthritis, Infectious - diagnosis ; Arthritis, Infectious - microbiology ; Blood Culture - methods ; blood culture bottles ; Blood Sedimentation ; C-Reactive Protein - analysis ; conventional culture ; diagnostic tool ; Female ; Humans ; lower extremity arthroplasty ; Male ; Middle Aged ; Orthopedics ; periprosthetic joint infection ; Prospective Studies ; Prosthesis-Related Infections - diagnosis ; Prosthesis-Related Infections - microbiology ; Synovial Fluid - chemistry ; Synovial Fluid - microbiology</subject><ispartof>The Journal of arthroplasty, 2016-08, Vol.31 (8), p.1779-1783</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-ab89c130e798c3d922af1b0fbb32361431b41588f227963e4af819637a868bae3</citedby><cites>FETCH-LOGICAL-c477t-ab89c130e798c3d922af1b0fbb32361431b41588f227963e4af819637a868bae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27020677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geller, Jeffrey A., MD</creatorcontrib><creatorcontrib>MacCallum, Katherine P., MD</creatorcontrib><creatorcontrib>Murtagh, Taylor S., BS</creatorcontrib><creatorcontrib>Patrick, David A., BS</creatorcontrib><creatorcontrib>Liabaud, Barthelemy, MD</creatorcontrib><creatorcontrib>Jonna, Venkata K., MD</creatorcontrib><title>Prospective Comparison of Blood Culture Bottles and Conventional Swabs for Microbial Identification of Suspected Periprosthetic Joint Infection</title><title>The Journal of arthroplasty</title><addtitle>J Arthroplasty</addtitle><description>Abstract Background Early, accurate detection of infection is vital to successful treatment of periprosthetic joint infection (PJI). Currently, no “gold standard” diagnostic testing exists. The goal of this prospective study was to compare the efficacy of a blood culture bottle system (BCBS) to commonly used culture swabs in confirming PJI in patients with high clinical suspicion. Methods Patients were selected for enrollment based on Musculoskeletal Infection Society guidelines for PJI. ESR and CRP were obtained prior to aspiration. Aspirated fluid was divided between BCBS, swab, and synovial fluid analysis. Forty-nine samples were analyzed. Results BCBS yielded 41 positive cultures versus 19 with swab (p<0.0001), particularly with respect to S. epidermidis . There were no false positive results in the BCBS group, using strict Musculoskeletal Infection Society guidelines. Conclusion BCBS increased identification of pathogens in lower extremity PJI, providing clinicians with a low-cost, broadly-applicable test.</description><subject>Adult</subject><subject>Aged</subject><subject>Arthritis, Infectious - diagnosis</subject><subject>Arthritis, Infectious - microbiology</subject><subject>Blood Culture - methods</subject><subject>blood culture bottles</subject><subject>Blood Sedimentation</subject><subject>C-Reactive Protein - analysis</subject><subject>conventional culture</subject><subject>diagnostic tool</subject><subject>Female</subject><subject>Humans</subject><subject>lower extremity arthroplasty</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Orthopedics</subject><subject>periprosthetic joint infection</subject><subject>Prospective Studies</subject><subject>Prosthesis-Related Infections - diagnosis</subject><subject>Prosthesis-Related Infections - microbiology</subject><subject>Synovial Fluid - chemistry</subject><subject>Synovial Fluid - microbiology</subject><issn>0883-5403</issn><issn>1532-8406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9UstuEzEUtRAVTQs_wAJ5yWYGP-bhSAiJRqUEtaJSYG15PNeqw8QOtieoX8Ev1yaFBYuufHV9zn2ccxF6TUlNCe3ebWsV0l3NclwTVhPaPEML2nJWiYZ0z9GCCMGrtiH8FJ3FuCWE0rZtXqBT1hNGur5foN-3wcc96GQPgFd-t1fBRu-wN_hi8n7Eq3lKcwB84VOaIGLlcs67A7hkvVMT3vxSQ8TGB3xjdfCDzbn1WL6N1aqASrHN_KcLjPgWgt3npukOktX4i7cu4bUzZQbvXqITo6YIrx7fc_T90-W31efq-uvVevXxutJN36dKDWKpKSfQL4Xm45IxZehAzDBwxjvacDo0tBXCMNYvOw6NMoLmoFeiE4MCfo7eHuvmUX7OEJPc2ahhmpQDP0dJBemJKDJnKDtC83YxBjByH-xOhXtJiSwIuZXFCFmMkITJbEQmvXmsPw87GP9R_iqfAe-PAMhbHiwEGbUFp2G0IUshR2-frv_hP7qerMuCTz_gHuLWzyGbk_eQMRPkppxCuQTa5SvgOXgAg0Gw1g</recordid><startdate>20160801</startdate><enddate>20160801</enddate><creator>Geller, Jeffrey A., MD</creator><creator>MacCallum, Katherine P., MD</creator><creator>Murtagh, Taylor S., BS</creator><creator>Patrick, David A., BS</creator><creator>Liabaud, Barthelemy, MD</creator><creator>Jonna, Venkata K., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160801</creationdate><title>Prospective Comparison of Blood Culture Bottles and Conventional Swabs for Microbial Identification of Suspected Periprosthetic Joint Infection</title><author>Geller, Jeffrey A., MD ; MacCallum, Katherine P., MD ; Murtagh, Taylor S., BS ; Patrick, David A., BS ; Liabaud, Barthelemy, MD ; Jonna, Venkata K., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-ab89c130e798c3d922af1b0fbb32361431b41588f227963e4af819637a868bae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthritis, Infectious - diagnosis</topic><topic>Arthritis, Infectious - microbiology</topic><topic>Blood Culture - methods</topic><topic>blood culture bottles</topic><topic>Blood Sedimentation</topic><topic>C-Reactive Protein - analysis</topic><topic>conventional culture</topic><topic>diagnostic tool</topic><topic>Female</topic><topic>Humans</topic><topic>lower extremity arthroplasty</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Orthopedics</topic><topic>periprosthetic joint infection</topic><topic>Prospective Studies</topic><topic>Prosthesis-Related Infections - diagnosis</topic><topic>Prosthesis-Related Infections - microbiology</topic><topic>Synovial Fluid - chemistry</topic><topic>Synovial Fluid - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geller, Jeffrey A., MD</creatorcontrib><creatorcontrib>MacCallum, Katherine P., MD</creatorcontrib><creatorcontrib>Murtagh, Taylor S., BS</creatorcontrib><creatorcontrib>Patrick, David A., BS</creatorcontrib><creatorcontrib>Liabaud, Barthelemy, MD</creatorcontrib><creatorcontrib>Jonna, Venkata K., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of arthroplasty</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geller, Jeffrey A., MD</au><au>MacCallum, Katherine P., MD</au><au>Murtagh, Taylor S., BS</au><au>Patrick, David A., BS</au><au>Liabaud, Barthelemy, MD</au><au>Jonna, Venkata K., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective Comparison of Blood Culture Bottles and Conventional Swabs for Microbial Identification of Suspected Periprosthetic Joint Infection</atitle><jtitle>The Journal of arthroplasty</jtitle><addtitle>J Arthroplasty</addtitle><date>2016-08-01</date><risdate>2016</risdate><volume>31</volume><issue>8</issue><spage>1779</spage><epage>1783</epage><pages>1779-1783</pages><issn>0883-5403</issn><eissn>1532-8406</eissn><abstract>Abstract Background Early, accurate detection of infection is vital to successful treatment of periprosthetic joint infection (PJI). Currently, no “gold standard” diagnostic testing exists. The goal of this prospective study was to compare the efficacy of a blood culture bottle system (BCBS) to commonly used culture swabs in confirming PJI in patients with high clinical suspicion. Methods Patients were selected for enrollment based on Musculoskeletal Infection Society guidelines for PJI. ESR and CRP were obtained prior to aspiration. Aspirated fluid was divided between BCBS, swab, and synovial fluid analysis. Forty-nine samples were analyzed. Results BCBS yielded 41 positive cultures versus 19 with swab (p<0.0001), particularly with respect to S. epidermidis . There were no false positive results in the BCBS group, using strict Musculoskeletal Infection Society guidelines. Conclusion BCBS increased identification of pathogens in lower extremity PJI, providing clinicians with a low-cost, broadly-applicable test.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>27020677</pmid><doi>10.1016/j.arth.2016.02.014</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Arthritis, Infectious - diagnosis Arthritis, Infectious - microbiology Blood Culture - methods blood culture bottles Blood Sedimentation C-Reactive Protein - analysis conventional culture diagnostic tool Female Humans lower extremity arthroplasty Male Middle Aged Orthopedics periprosthetic joint infection Prospective Studies Prosthesis-Related Infections - diagnosis Prosthesis-Related Infections - microbiology Synovial Fluid - chemistry Synovial Fluid - microbiology |
| title | Prospective Comparison of Blood Culture Bottles and Conventional Swabs for Microbial Identification of Suspected Periprosthetic Joint Infection |
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