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Relationship Between Urinary 8-hydroxydeoxyguanine (8-OHdG) Levels and Clinicopathological Findings in Hepatobiliary Malignancies
Oxidative stress is defined as an imbalance between the pro-oxidant and antioxidant potential of cells leading to intracellular DNA damage. To clarify the oxidative stress response as a tumor marker, we investigated measurement of urinary 8-hydroxydeoxyguanosine (8-OHdG) levels in hepatobiliary dise...
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| Published in: | Anticancer research 2016-08, Vol.36 (8), p.3899-3903 |
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| container_title | Anticancer research |
| container_volume | 36 |
| creator | Nanashima, Atsushi Izumino, Hiroo Sumida, Yorihisa Tominaga, Tetsuro Wakata, Kouki Hidaka, Shigekazu Tsuchiya, Tomoshi Nagayasu, Takeshi |
| description | Oxidative stress is defined as an imbalance between the pro-oxidant and antioxidant potential of cells leading to intracellular DNA damage. To clarify the oxidative stress response as a tumor marker, we investigated measurement of urinary 8-hydroxydeoxyguanosine (8-OHdG) levels in hepatobiliary diseases.
Relationships between urinary 8-OHdG levels and clinicopathological factors were analyzed in 101 patients, including 84 with hepatobiliary malignancies, and 18 healthy volunteers. Co-existing biliary inflammation was detected in 8 patients.
Urinary 8-OHdG levels did not correlate with any clinical or liver functional parameters. The existence of inflammation and any tumor-related factor did not correlate with urinary 8-OHdG levels either. Urinary 8-OHdG levels were significantly higher in patients with benign and malignant diseases than in healthy volunteers (p |
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Relationships between urinary 8-OHdG levels and clinicopathological factors were analyzed in 101 patients, including 84 with hepatobiliary malignancies, and 18 healthy volunteers. Co-existing biliary inflammation was detected in 8 patients.
Urinary 8-OHdG levels did not correlate with any clinical or liver functional parameters. The existence of inflammation and any tumor-related factor did not correlate with urinary 8-OHdG levels either. Urinary 8-OHdG levels were significantly higher in patients with benign and malignant diseases than in healthy volunteers (p<0.05), but not significantly different between benign and malignant diseases. Among patients with intrahepatic cholangiocarcinoma and gallbladder carcinoma, urinary 8-OHdG levels tended to be higher in patients with lymph node metastasis-positive than in those with lymph node-negative disease (p=0.057).
The clinical significance of oxidative DNA damage and increases in its urinary metabolites in patients with hepatobiliary malignancies or inflammatory diseases remain unknown. Further studies are necessary to clarify the relationship between node metastasis and oxidative stress as a prognostic marker.</description><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 27466492</identifier><language>eng</language><publisher>Greece</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - urine ; Cholangiocarcinoma - pathology ; Cholangiocarcinoma - surgery ; Cholangiocarcinoma - urine ; DNA Damage - genetics ; Female ; Gallbladder Neoplasms - pathology ; Gallbladder Neoplasms - surgery ; Gallbladder Neoplasms - urine ; Guanine - analogs & derivatives ; Guanine - urine ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Oxidative Stress - genetics ; Reactive Oxygen Species - metabolism</subject><ispartof>Anticancer research, 2016-08, Vol.36 (8), p.3899-3903</ispartof><rights>Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27466492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nanashima, Atsushi</creatorcontrib><creatorcontrib>Izumino, Hiroo</creatorcontrib><creatorcontrib>Sumida, Yorihisa</creatorcontrib><creatorcontrib>Tominaga, Tetsuro</creatorcontrib><creatorcontrib>Wakata, Kouki</creatorcontrib><creatorcontrib>Hidaka, Shigekazu</creatorcontrib><creatorcontrib>Tsuchiya, Tomoshi</creatorcontrib><creatorcontrib>Nagayasu, Takeshi</creatorcontrib><title>Relationship Between Urinary 8-hydroxydeoxyguanine (8-OHdG) Levels and Clinicopathological Findings in Hepatobiliary Malignancies</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>Oxidative stress is defined as an imbalance between the pro-oxidant and antioxidant potential of cells leading to intracellular DNA damage. To clarify the oxidative stress response as a tumor marker, we investigated measurement of urinary 8-hydroxydeoxyguanosine (8-OHdG) levels in hepatobiliary diseases.
Relationships between urinary 8-OHdG levels and clinicopathological factors were analyzed in 101 patients, including 84 with hepatobiliary malignancies, and 18 healthy volunteers. Co-existing biliary inflammation was detected in 8 patients.
Urinary 8-OHdG levels did not correlate with any clinical or liver functional parameters. The existence of inflammation and any tumor-related factor did not correlate with urinary 8-OHdG levels either. Urinary 8-OHdG levels were significantly higher in patients with benign and malignant diseases than in healthy volunteers (p<0.05), but not significantly different between benign and malignant diseases. Among patients with intrahepatic cholangiocarcinoma and gallbladder carcinoma, urinary 8-OHdG levels tended to be higher in patients with lymph node metastasis-positive than in those with lymph node-negative disease (p=0.057).
The clinical significance of oxidative DNA damage and increases in its urinary metabolites in patients with hepatobiliary malignancies or inflammatory diseases remain unknown. Further studies are necessary to clarify the relationship between node metastasis and oxidative stress as a prognostic marker.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - urine</subject><subject>Cholangiocarcinoma - pathology</subject><subject>Cholangiocarcinoma - surgery</subject><subject>Cholangiocarcinoma - urine</subject><subject>DNA Damage - genetics</subject><subject>Female</subject><subject>Gallbladder Neoplasms - pathology</subject><subject>Gallbladder Neoplasms - surgery</subject><subject>Gallbladder Neoplasms - urine</subject><subject>Guanine - analogs & derivatives</subject><subject>Guanine - urine</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxidative Stress - genetics</subject><subject>Reactive Oxygen Species - metabolism</subject><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNo1UE1Lw0AUDILYWv0Lssd6CGw2X5ujFtsKlYLYc3jZfUmfbHdjNlF77D83Yp3DzGGGYZiLYBrlRRTmacwnwbX375xnWSHjq2Ai8iTLkkJMg9MrGujJWb-nlj1i_4Vo2a4jC92RyXB_1J37PmocqRnAkkU2l-F2rVf3bIOfaDwDq9nCkCXlWuj3zriGFBi2JKvJNp6RZWscLVeRod_eFzDUWLCK0N8ElzUYj7dnnQW75dPbYh1utqvnxcMmbEUU9aGqQVdQ5LzWCFVScSkwVRgLTFKOacFrLpIEdV0LWUPMOSilxAgexZihjmfB_K-37dzHgL4vD-QVGgMW3eDLSPJcSlkk-Ri9O0eH6oC6bDs6jLPL_9viH8uHa3Q</recordid><startdate>201608</startdate><enddate>201608</enddate><creator>Nanashima, Atsushi</creator><creator>Izumino, Hiroo</creator><creator>Sumida, Yorihisa</creator><creator>Tominaga, Tetsuro</creator><creator>Wakata, Kouki</creator><creator>Hidaka, Shigekazu</creator><creator>Tsuchiya, Tomoshi</creator><creator>Nagayasu, Takeshi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201608</creationdate><title>Relationship Between Urinary 8-hydroxydeoxyguanine (8-OHdG) Levels and Clinicopathological Findings in Hepatobiliary Malignancies</title><author>Nanashima, Atsushi ; Izumino, Hiroo ; Sumida, Yorihisa ; Tominaga, Tetsuro ; Wakata, Kouki ; Hidaka, Shigekazu ; Tsuchiya, Tomoshi ; Nagayasu, Takeshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p211t-cfadba970fdeab4b082e5ce32e450e590f0244edff28fa300accc2222013e6ed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - urine</topic><topic>Cholangiocarcinoma - pathology</topic><topic>Cholangiocarcinoma - surgery</topic><topic>Cholangiocarcinoma - urine</topic><topic>DNA Damage - genetics</topic><topic>Female</topic><topic>Gallbladder Neoplasms - pathology</topic><topic>Gallbladder Neoplasms - surgery</topic><topic>Gallbladder Neoplasms - urine</topic><topic>Guanine - analogs & derivatives</topic><topic>Guanine - urine</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxidative Stress - genetics</topic><topic>Reactive Oxygen Species - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nanashima, Atsushi</creatorcontrib><creatorcontrib>Izumino, Hiroo</creatorcontrib><creatorcontrib>Sumida, Yorihisa</creatorcontrib><creatorcontrib>Tominaga, Tetsuro</creatorcontrib><creatorcontrib>Wakata, Kouki</creatorcontrib><creatorcontrib>Hidaka, Shigekazu</creatorcontrib><creatorcontrib>Tsuchiya, Tomoshi</creatorcontrib><creatorcontrib>Nagayasu, Takeshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nanashima, Atsushi</au><au>Izumino, Hiroo</au><au>Sumida, Yorihisa</au><au>Tominaga, Tetsuro</au><au>Wakata, Kouki</au><au>Hidaka, Shigekazu</au><au>Tsuchiya, Tomoshi</au><au>Nagayasu, Takeshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship Between Urinary 8-hydroxydeoxyguanine (8-OHdG) Levels and Clinicopathological Findings in Hepatobiliary Malignancies</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2016-08</date><risdate>2016</risdate><volume>36</volume><issue>8</issue><spage>3899</spage><epage>3903</epage><pages>3899-3903</pages><eissn>1791-7530</eissn><abstract>Oxidative stress is defined as an imbalance between the pro-oxidant and antioxidant potential of cells leading to intracellular DNA damage. To clarify the oxidative stress response as a tumor marker, we investigated measurement of urinary 8-hydroxydeoxyguanosine (8-OHdG) levels in hepatobiliary diseases.
Relationships between urinary 8-OHdG levels and clinicopathological factors were analyzed in 101 patients, including 84 with hepatobiliary malignancies, and 18 healthy volunteers. Co-existing biliary inflammation was detected in 8 patients.
Urinary 8-OHdG levels did not correlate with any clinical or liver functional parameters. The existence of inflammation and any tumor-related factor did not correlate with urinary 8-OHdG levels either. Urinary 8-OHdG levels were significantly higher in patients with benign and malignant diseases than in healthy volunteers (p<0.05), but not significantly different between benign and malignant diseases. Among patients with intrahepatic cholangiocarcinoma and gallbladder carcinoma, urinary 8-OHdG levels tended to be higher in patients with lymph node metastasis-positive than in those with lymph node-negative disease (p=0.057).
The clinical significance of oxidative DNA damage and increases in its urinary metabolites in patients with hepatobiliary malignancies or inflammatory diseases remain unknown. Further studies are necessary to clarify the relationship between node metastasis and oxidative stress as a prognostic marker.</abstract><cop>Greece</cop><pmid>27466492</pmid><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - urine Cholangiocarcinoma - pathology Cholangiocarcinoma - surgery Cholangiocarcinoma - urine DNA Damage - genetics Female Gallbladder Neoplasms - pathology Gallbladder Neoplasms - surgery Gallbladder Neoplasms - urine Guanine - analogs & derivatives Guanine - urine Humans Lymphatic Metastasis Male Middle Aged Oxidative Stress - genetics Reactive Oxygen Species - metabolism |
| title | Relationship Between Urinary 8-hydroxydeoxyguanine (8-OHdG) Levels and Clinicopathological Findings in Hepatobiliary Malignancies |
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