Sex-related differences in baseline characteristics, management and outcome in patients with acute coronary syndrome without ST-segment elevation

Aim: To detect sex-related differences in baseline characteristics, management and outcome in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Methods: Data from 812 consecutive patients admitted to our cardiology department for NSTE-ACS between 2001 and 2004 were obtained....

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Published in:European heart journal. Acute cardiovascular care 2016-08, Vol.5 (4), p.347-353
Main Authors: Vogel, Birgit, Farhan, Serdar, Hahne, Sarah, Kozanli, Ilyas, Kalla, K, Freynhofer, Matthias K, Jarai, Rudolf, Kautzky-Willer, Alexandra, Huber, Kurt
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - diagnosis
Acute Coronary Syndrome - mortality
Acute Coronary Syndrome - therapy
Aged
Aged, 80 and over
Coronary Angiography - methods
Disease Management
Female
Hospital Mortality
Humans
Male
Middle Aged
Percutaneous Coronary Intervention - methods
Proportional Hazards Models
Sex Factors
Treatment Outcome
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Summary:Aim: To detect sex-related differences in baseline characteristics, management and outcome in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). Methods: Data from 812 consecutive patients admitted to our cardiology department for NSTE-ACS between 2001 and 2004 were obtained. Early invasive therapy was defined as revascularization during first hospital stay. A seven-year follow-up for the clinical endpoint of all-cause mortality could be obtained in 342 women and 440 men, respectively. Results: Compared with men, women were significantly older and more likely to suffer from renal insufficiency. The proportion treated with clopidogrel at admission was 43.6% for women and 52.7% for men, respectively (p=0.011). Significantly fewer women underwent an early invasive therapy compared with men (27.5% vs. 35.2%; p=0.021). Age and renal insufficiency were the strongest predictors for a conservative approach in both female and male patients. After adjustment for baseline characteristics there was no significant difference in treatment between women and men (odds ratio 0.89; 95% confidence interval 0.59–1.35; p=0.588). While in-hospital mortality was similar between the sexes, long-term mortality was significantly higher in women compared with men (8.2% vs. 7.0%; p=0.549 for in-hospital mortality and 54.8% vs. 39.3%; p
ISSN:2048-8726
2048-8734
DOI:10.1177/2048872615585514