ERF115 Controls Root Quiescent Center Cell Division and Stem Cell Replenishment

The quiescent center (QC) plays an essential role during root development by creating a microenvironment that preserves the stem cell fate of its surrounding cells. Despite being surrounded by highly mitotic active cells, QC cells self-renew at a low proliferation rate. Here, we identified the ERF11...

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Published in:Science (American Association for the Advancement of Science) 2013-11, Vol.342 (6160), p.860-863
Main Authors: Heyman, Jefri, Cools, Toon, Vandenbussche, Filip, Heyndrickx, Ken S., Van Leene, Jelle, Vercauteren, Ilse, Vanderauwera, Sandy, Vandepoele, Klaas, De Jaeger, Geert, Van Der Straeten, Dominique, De Veylder, Lieven
Format: Article
Language:English
Subjects:
Activation
Anaphase-Promoting Complex-Cyclosome - metabolism
Arabidopsis - cytology
Arabidopsis - growth & development
Arabidopsis Proteins - genetics
Arabidopsis Proteins - metabolism
Brasses
Brassinosteroids
Cell cycle
Cell Cycle - genetics
Cell Cycle - physiology
Cell Cycle Proteins - metabolism
Cell division
Cell Division - genetics
Cell Division - physiology
Cell growth
Differentiation
Genes
Individualized Instruction
Maintenance
Mitosis - genetics
Mitosis - physiology
Peptide Hormones - genetics
Peptide Hormones - metabolism
Plant cells
Plant Roots - cytology
Plant Roots - growth & development
Plants
Proteins
Proteolysis
Replenishment
Root tips
Roots
Signal Transduction
Stem Cell Niche
Stem cells
Stem Cells - physiology
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:The quiescent center (QC) plays an essential role during root development by creating a microenvironment that preserves the stem cell fate of its surrounding cells. Despite being surrounded by highly mitotic active cells, QC cells self-renew at a low proliferation rate. Here, we identified the ERF115 transcription factor as a rate-limiting factor of QC cell division, acting as a transcriptional activator of the phytosulfokine PSK5 peptide hormone. ERF115 marks QC cell division but is restrained through proteolysis by the APC/C CCS52A2 ubiquitin ligase, whereas QC proliferation is driven by brassinosteroid-dependent ERF115 expression. Together, these two antagonistic mechanisms delimit ERF115 activity, which is called upon when surrounding stem cells are damaged, revealing a cell cycle regulatory mechanism accounting for stem cell niche longevity.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1240667