Blueberry (Vaccinium virgatum Aiton) Leaf Infusion Ameliorates Insulin Resistance in Mice Fed a High-fat, High-sucrose Diet

Blueberry (Vaccinium virgatum Aiton) leaf extract (BLEx) has attracted attention as a beneficial food component. Here, we examined the effect of dietary BLEx on glucose and lipid metabolism in mice fed a high-fat, high-sucrose diet (HFHSD). Growth parameter data showed that 3% BLEx slightly reduced...

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Published in:FOOD SCIENCE AND TECHNOLOGY RESEARCH 2015, Vol.21(6), pp.827-833
Main Authors: Yamasaki, Masao, Matsuyama, Yusuke, Hayasegawa, Rintaro, Hamada, Kensaku, Nishiyama, Kazuo, Kai, Takanori, Kamenaga, Kozo, Arakawa, Teruaki, Tari, Hiroyuki, Shimizu, Yoshio, Matsuura, Yasushi, Yukizaki, Chizuko
Format: Article
Language:English
Subjects:
Blueberries
blueberry leaf
Diets
Fasting
Glucose
high-fat
high-sucrose diet
Insulin
insulin resistance
Mice
Serums
Weight reduction
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Summary:Blueberry (Vaccinium virgatum Aiton) leaf extract (BLEx) has attracted attention as a beneficial food component. Here, we examined the effect of dietary BLEx on glucose and lipid metabolism in mice fed a high-fat, high-sucrose diet (HFHSD). Growth parameter data showed that 3% BLEx slightly reduced body weight and adipose tissue weight accompanied by inhibition of HFHSD-induced enlargement of adipocytes. Liver weight was significantly reduced in the 3% BLEx group secondary to reduction of lipid accumulation in the hepatocytes. HFHSD-induced augmentation of fasting serum glucose levels was ameliorated by 3% BLEx. HFHSD-induced increase of fasting serum insulin level, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) also tended to be ameliorated. Oral glucose tolerance tests (OGTTs) revealed that 3% BLEx normalized HFHSD-induced elevation of the area under the curve for serum glucose, whereas dietary BLEx, even for the 3% dose, did not have a suppressive effect on the serum glucose change after OGTT. Taken together, these observations suggest that BLEx is a promising agent for the prevention of HFHSD-induced insulin resistance.
ISSN:1344-6606
1881-3984
DOI:10.3136/fstr.21.827