Effects of Proton and Combined Proton and super( 56)Fe Radiation on the Hippocampus

In this study, the authors first determined the dose-response effect of proton radiation (150 MeV) on hippocampus-dependent cognition 1 and 3 months after exposure. Based on those results, they subsequently exposed mice to protons alone (150 MeV, 0.1 Gy), super( 56)Fe alone (600 MeV/n, 0.5 Gy) or co...

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Bibliographic Details
Published in:Radiation research 2016-01, Vol.185 (1), p.20-20
Main Authors: Raber, Jacob, Allen, Antino R, Sharma, Sourabh, Allen, Barrett, Rosi, Susanna, Olsen, Reid H J, Davis, Matthew Mname>J, Eiwaz, Massarra, Fike, John R, Nelson, Gregory A
Format: Article
Language:English
Subjects:
Activated
Cognition
Exposure
Hippocampus
Injuries
Mice
Object recognition
Receiving
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Summary:In this study, the authors first determined the dose-response effect of proton radiation (150 MeV) on hippocampus-dependent cognition 1 and 3 months after exposure. Based on those results, they subsequently exposed mice to protons alone (150 MeV, 0.1 Gy), super( 56)Fe alone (600 MeV/n, 0.5 Gy) or combined proton and super( 56)Fe radiations (protons first) with the two exposures separated by 24 h. At one month postirradiation, all animal groups showed novel object recognition. However, at three months postirradiation, mice exposed to either protons or combined proton and super( 56)Fe radiations showed impaired novel object recognition, which was not observed in mice irradiated with super( 56)Fe alone. Finally, hippocampal IL-6 levels were higher in mice receiving combined radiations compared with mice receiving super( 56)Fe radiation alone. These data demonstrate the sensitivity of novel object recognition for detecting cognitive injury three months after exposure to proton radiation alone, and combined exposure to proton and super( 56)Fe radiations, and that newly-born activated microglia and inflammation might be involved in this injury.
ISSN:0033-7587
1938-5404
DOI:10.1667/RR14222.1