Exposure characterization of three major insecticide lines in urine of young children in Japan—neonicotinoids, organophosphates, and pyrethroids

The use of neonicotinoid (NEO) insecticides has increased over the past decade not only in Japan but also worldwide, while organophosphate (OP) and pyrethroid (PYR) insecticides are still conventionally used in agriculture and domestic pest control. However, limited data are currently available on t...

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Bibliographic Details
Published in:Environmental research 2016-05, Vol.147, p.89-96
Main Authors: Osaka, Aya, Ueyama, Jun, Kondo, Takaaki, Nomura, Hiroshi, Sugiura, Yuka, Saito, Isao, Nakane, Kunihiko, Takaishi, Ayuko, Ogi, Hiroko, Wakusawa, Shinya, Ito, Yuki, Kamijima, Michihiro
Format: Article
Language:English
Subjects:
Anabasine - urine
Biomonitoring
Child, Preschool
Children
Domestic
Environmental Exposure
Environmental Monitoring
Environmental Pollutants - urine
Exposure
Female
Humans
Insecticide
Insecticides
Insecticides - urine
Japan
Male
Metabolites
Neonicotinoid
Organophosphates
Organophosphates - urine
Pyrethrins - urine
Summer
Urine
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Summary:The use of neonicotinoid (NEO) insecticides has increased over the past decade not only in Japan but also worldwide, while organophosphate (OP) and pyrethroid (PYR) insecticides are still conventionally used in agriculture and domestic pest control. However, limited data are currently available on the NEO exposure levels, especially in children, who are particularly vulnerable to environmental toxicants. Thus, the purpose of this study was to characterize the exposure to NEOs, as well as OPs and PYRs, in three-year-old Japanese children by assessing the range, distribution, and seasonal differences of the urinary concentrations of seven NEOs (acetamiprid, clothianidin, dinotefuran, thiacloprid, thiamethoxam, imidacloprid, and nitenpyram); four OP metabolites (dialkylphosphates [DAPs]), including dimethylphosphate, dimethylthiophosphate, diethylphosphate, and diethylthiophosphate; and three PYR metabolites (3-phenoxybenzoic acid, trans-chrysanthemumdicarboxylic acid, and 3-(2,2-dichlorovinyl)-2,2- dimethylcyclopropane carboxylic acid). Urine samples were collected from 223 children (108 males and 115 females) in the summer and winter months. The detection rates of NEOs were 58% for dinotefuran, 25% for thiamethoxam, 21% for nitenpyram, and
ISSN:0013-9351
1096-0953
DOI:10.1016/j.envres.2016.01.028