Implications for reactive oxygen species in schizophrenia pathogenesis

Abstract Oxidative stress is a well-recognized participant in the pathophysiology of multiple brain disorders, particularly neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. While not a dementia, a wide body of evidence has also been accumulating for aberrant react...

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Bibliographic Details
Published in:Schizophrenia research 2016-09, Vol.176 (1), p.52-71
Main Authors: Koga, Minori, Serritella, Anthony V, Sawa, Akira, Sedlak, Thomas W
Format: Article
Language:English
Subjects:
Glutathione
Humans
Inflammation
Inflammation - immunology
Inflammation - metabolism
Microglia
Oxidative Stress
Psychiatry
Psychosis
Psychotic Disorders - immunology
Psychotic Disorders - metabolism
Reactive Oxygen Species
Schizophrenia
Schizophrenia - immunology
Schizophrenia - metabolism
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Summary:Abstract Oxidative stress is a well-recognized participant in the pathophysiology of multiple brain disorders, particularly neurodegenerative conditions such as Alzheimer's and Parkinson's diseases. While not a dementia, a wide body of evidence has also been accumulating for aberrant reactive oxygen species and inflammation in schizophrenia. Here we highlight roles for oxidative stress as a common mechanism by which varied genetic and epidemiologic risk factors impact upon neurodevelopmental processes that underlie the schizophrenia syndrome. While there is longstanding evidence that schizophrenia may not have a single causative lesion, a common pathway involving oxidative stress opens the possibility for intervention at susceptible phases.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2015.06.022