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Protein intake in early childhood and body composition at the age of 6 years: The Generation R Study

Background: Previous studies suggest that high protein intake in infancy leads to a higher body mass index (BMI) in later childhood. We examined the associations of total, animal and vegetable protein intake in early childhood with detailed measures of body composition at the age of 6 years. Methods...

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Published in:International Journal of Obesity 2016-06, Vol.40 (6), p.1018-1025
Main Authors: Voortman, T, Braun, K V E, Kiefte-de Jong, J C, Jaddoe, V W V, Franco, O H, van den Hooven, E H
Format: Article
Language:English
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Summary:Background: Previous studies suggest that high protein intake in infancy leads to a higher body mass index (BMI) in later childhood. We examined the associations of total, animal and vegetable protein intake in early childhood with detailed measures of body composition at the age of 6 years. Methods: This study was performed in 2911 children participating in a population-based cohort study. Protein intake at the age of 1 year was assessed with a validated food-frequency questionnaire and was adjusted for total energy intake. At the children’s age of 6 years, we measured their anthropometrics and body fat (with dual-energy X-ray absorptiometry). We calculated age- and sex-specific s.d. scores for BMI, fat mass index (FMI) and fat-free mass index (FFMI). Results: After adjustment for confounders, a 10 g per day higher total protein intake at 1 year of age was associated with a 0.05 s.d. (95% confidence interval (CI) 0.00, 0.09) higher BMI at age 6. This association was fully driven by a higher FMI (0.06 s.d. (95%CI 0.01, 0.11)) and not FFMI (−0.01 s.d. (95%CI −0.06, 0.05)). The associations of protein intake with FMI at 6 years remained significant after adjustment for BMI at the age of 1 year. Additional analyses showed that the associations of protein intake with FMI were stronger in girls than in boys ( P for interaction=0.03), stronger among children who had catch-up growth in the first year of life ( P for interaction
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2016.29