UVB exposure enhanced the dermal penetration of zinc oxide nanoparticles and induced inflammatory responses through oxidative stress mediated by MAPKs and NF-κB signaling in SKH-1 hairless mouse skin

Besides titanium dioxide (TiO ), zinc oxide (ZnO) nanoparticles (NPs) are commonly used in sunscreen formulations as protective agents against exposure to ultraviolet radiation. Although the majority of prior studies have concluded that NPs do not penetrate healthy skin, compromised skin slightly en...

Full description

Saved in:
Bibliographic Details
Published in:Toxicology research (Cambridge) 2016-01, Vol.5 (4), p.1066-1077
Main Authors: Pal, Anu, Alam, Shamshad, Chauhan, Lalit K S, Saxena, Prem N, Kumar, Mahadeo, Ansari, Ghazi N, Singh, Dhirendra, Ansari, Kausar M
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Besides titanium dioxide (TiO ), zinc oxide (ZnO) nanoparticles (NPs) are commonly used in sunscreen formulations as protective agents against exposure to ultraviolet radiation. Although the majority of prior studies have concluded that NPs do not penetrate healthy skin, compromised skin slightly enhanced metal oxide NP penetration. However, a question arises regarding the possible toxic consequences if consumers who had applied sunscreens containing ZnO-NPs were exposed to environmentally relevant doses of UVB. Considering this, we planned a study where SKH-1 hairless mice were topically exposed to a 5% and/or 10% dose of ZnO-NPs (
ISSN:2045-452X
2045-4538
DOI:10.1039/c6tx00026f