Central and peripheral blood pressures in relation to plasma advanced glycation end products in a Chinese population

• Published in: Journal of human hypertension 2016-07, Vol.30 (7), p.430-435
• Main Authors: Huang, Q-F, Sheng, C-S, Kang, Y-Y, Zhang, L, Wang, S, Li, F-K, Cheng, Y-B, Guo, Q-H, Li, Y, Wang, J-G
• Format: Article
• Language: English
• Subjects: 692/499; Adult; Advanced glycosylation end products; Age; Aged; Aorta; Biomarkers - blood; Blood Pressure; Body weight; Cardiovascular diseases; Cardiovascular Diseases - blood; Cardiovascular Diseases - diagnosis; Cardiovascular Diseases - etiology; Cardiovascular Diseases - physiopathology; China; Cross-Sectional Studies; Diabetes mellitus; Diagnosis; Enzyme-Linked Immunosorbent Assay; Epidemiology; Female; Glycation End Products, Advanced - blood; Glycosylation; Health Administration; Health aspects; Humans; Hypercholesterolemia; Hypertension; Male; Medicine; Medicine & Public Health; Middle Aged; Multivariate Analysis; original-article; Oscillometry - instrumentation; Overweight; Peripheral blood; Plasma; Population studies; Prediabetic state; Public Health; Pulse Wave Analysis; Risk Assessment; Risk Factors; Statistical analysis; Vascular Stiffness
• ISSN: 0950-9240; 1476-5527
• DOI: 10.1038/jhh.2015.60

We investigated the association of plasma AGE (advanced glycation end product) concentration with central and peripheral blood pressures and central-to-brachial blood pressure amplification in a Chinese population. The study subjects were from a newly established residential area in the suburb of Shanghai. Using the SphygmoCor system, we recorded radial arterial waveforms and derived aortic waveforms by a generalized transfer function and central systolic and pulse pressure by calibration for brachial blood pressure measured with an oscillometric device. The central-to-brachial pressure amplification was expressed as the central-to-brachial systolic blood pressure difference and pulse pressure difference and ratio. Plasma AGE concentration was measured by the enzyme-linked immunosorbent assay method and logarithmically transformed for statistical analysis. The 1051 participants (age, 55.1±13.1 years) included 663 women. After adjustment for sex, age and other confounding factors, plasma AGE concentration was associated with central but not peripheral blood pressures and with some of the pressure amplification indexes. Indeed, each 10-fold increase in plasma AGE concentration was associated with 2.94 mm Hg ( P =0.04) higher central systolic blood pressure and 2.39% lower central-to-brachial pulse pressure ratio ( P =0.03). In further subgroup analyses, the association was more prominent in the presence of hypercholesterolemia (+8.11 mm Hg, P =0.008) for central systolic blood pressure and in the presence of overweight and obesity (−4.89%, P =0.009), diabetes and prediabetes (−6.26%, P =0.10) or current smoking (−6.68%, P =0.045) for central-to-brachial pulse pressure ratio. In conclusion, plasma AGE concentration is independently associated with central systolic blood pressure and pulse pressure amplification, especially in the presence of several modifiable cardiovascular risk factors.