ED-29 THE INCIDENCE OF ADULT AND PEDIATRIC INTRACRANIAL EPENDYMOMAS WITHIN THE SCOTT AND WHITE INTEGRATED HEALTHCARE SYSTEM

• Published in: Neuro-oncology (Charlottesville, Va.) Va.), 2014-11, Vol.16 (suppl 5), p.v72-v72
• Main Authors: Shephard, R., Singel, S., Fonkem, E.
• Format: Article
• Language: English
• ISSN: 1522-8517; 1523-5866
• DOI: 10.1093/neuonc/nou253.29

INTRODUCTION: Ependymomas are characterized by their higher incidence in children and by their rarity, especially among adult groups. Indeed, it has been difficult to reach a consensus on the most effective treatments. The purpose of this study was to determine how the outcome of adult and pediatric ependymomas is affected by various factors including age, ethnicity, tumor grade, and tumor type. METHODS: We conducted a retrospective analysis of ependymoma patients within the Scott and White brain tumor registry from 1976-2011. Data was analyzed regarding age, ethnicity, treatment interval, geographic distribution, tumor grade (Grade I - anaplastic), and tumor type (ependymoma and subependymoma). Analyses included univariate and multivariate methods. RESULTS: This study includes 28 patients within the Scott and White brain tumor registry from 1976-2011. All of the patients were subject to the same analyses. Of those 28 patients, 5 had subependymomas. 0f the 23 ependymoma cases, 2 were anaplastic. The remaining were either Grade I or Grade II. 19 of the 28 patients, or 68%, were of white ethnicity, the remainder of black, Hispanic, or other/unknown ethnicity. Additionally, 40% of the subependymoma patients were of white ethnicity. Survival rates were found to be in concordance with the current standards: 40-65% for pediatric cases and 55-90% for adult cases. We observed no death among the subependymoma group and thus a concurrent increase in the median survival of this group. The median survival time of the anaplastic ependymoma group was more difficult to quantify due to a limited number of cases and because the patients of this group are still alive. CONCLUSION: This study suggests that age is intimately involved with the development of ependymomas and subependymomas. White/Caucasian ethnicity also seems to correlate with the growth of subependymomas and ependymomas moreso than is seen in the other ethnicities of this study.