Association between depression and anemia in otherwise healthy adults

Objective It remains debated whether anemia is associated with depression, independently of physical health factors. We report a large‐scale cross‐sectional study examining this association in adults free of chronic disease and medication from the general population. Method Hemoglobin levels were me...

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Bibliographic Details
Published in:Acta psychiatrica Scandinavica 2016-08, Vol.134 (2), p.150-160
Main Authors: Vulser, H., Wiernik, E., Hoertel, N., Thomas, F., Pannier, B., Czernichow, S., Hanon, O., Simon, T., Simon, J-M, Danchin, N., Limosin, F., Lemogne, C.
Format: Article
Language:English
Subjects:
Adult
Anemia
Anemia - blood
Anemia - epidemiology
Anemia - psychology
Cohort Studies
cohort study
Cross-Sectional Studies
depression
Depression - blood
Depression - epidemiology
epidemiology
Female
France - epidemiology
hemoglobin
Hemoglobins - metabolism
Humans
Logistic Models
Male
Mental depression
Middle Aged
Prevalence
Psychiatry
Socioeconomic Factors
Surveys and Questionnaires
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Summary:Objective It remains debated whether anemia is associated with depression, independently of physical health factors. We report a large‐scale cross‐sectional study examining this association in adults free of chronic disease and medication from the general population. Method Hemoglobin levels were measured among 44 173 healthy participants [63% men; mean [standard deviation] age = 38.4 (11.1) years] from the ‘Investigations Préventives et Cliniques’ (IPC) cohort study. Depression was measured with the Questionnaire of Depression 2nd version, Abridged. Logistic regression analyses were performed to examine the association between anemia and depression, while adjusting for a wide range of sociodemographic characteristics and health‐related factors (i.e., sex, age, living status, education level, occupational status, alcohol intake, smoking status, physical activity, and body mass index). Results Depressed participants were significantly more likely to have anemia compared to non‐depressed participants, even after adjustment for sociodemographic and health‐related variables [odds ratio = 1.36; 95% confidence interval = (1.18; 1.57)]. Anemia prevalence increased with depression severity, suggesting a dose–response relationship (P for trend
ISSN:0001-690X
1600-0447
DOI:10.1111/acps.12595