Intensity-modulated radiotherapy or volumetric-modulated arc therapy in patients with head and neck cancer: Focus on salivary glands dosimetry

Background Despite radiotherapy (RT) technical improvements, high salivary dysfunction rates are still reported in patients with head and neck squamous cell carcinoma (HNSCC). The purpose of the present study was to report salivary glands dosimetry with volumetric‐modulated arc therapy (VMAT) and in...

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Bibliographic Details
Published in:Head & neck 2016-07, Vol.38 (7), p.1028-1034
Main Authors: Vallard, Alexis, Guy, Jean-Baptiste, Mengue Ndong, Sylvie, Vial, Nicolas, Rivoirard, Romain, Auberdiac, Pierre, Méry, Benoîte, Langrand-Escure, Julien, Espenel, Sophie, Moncharmont, Coralie, Ben Mrad, Majed, Diao, Peng, Goyet, Dominique, Magné, Nicolas
Format: Article
Language:English
Subjects:
Adult
Aged
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - radiotherapy
Cohort Studies
Dose-Response Relationship, Radiation
dosimetry
Female
Head and Neck Neoplasms - mortality
Head and Neck Neoplasms - pathology
Head and Neck Neoplasms - radiotherapy
Humans
intensity-modulated radiotherapy
Male
Middle Aged
Organs at Risk - radiation effects
parotid gland
Prognosis
Radiation Injuries - prevention & control
Radiometry
Radiotherapy Dosage
Radiotherapy, Intensity-Modulated - methods
Retrospective Studies
Salivary Glands - radiation effects
Squamous Cell Carcinoma of Head and Neck
submandibular gland
Survival Analysis
Treatment Outcome
volumetric-modulated arc therapies
Xerostomia - prevention & control
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Summary:Background Despite radiotherapy (RT) technical improvements, high salivary dysfunction rates are still reported in patients with head and neck squamous cell carcinoma (HNSCC). The purpose of the present study was to report salivary glands dosimetry with volumetric‐modulated arc therapy (VMAT) and intensity‐modulated RT (IMRT). Methods Dosimetry of consecutive patients receiving IMRT or VMAT for proven HNSCC between 2007 and 2013 were retrospectively reviewed. Results Data of 609 patients were studied. Mean dose, mean maximum dose, and mean percentage of salivary gland volume receiving at least 26 Gy (V26) of the contralateral parotid were 24.50 Gy (range, 0–70.4 Gy), 39.08 Gy (range, 0.38–76.45 Gy), and 40.92% (range, 0% to 100%), respectively. Mean and maximum dose on contralateral submandibular gland were 48.18 Gy (range, 0.19–70.73 Gy), and 61.25 Gy (range, 0–75.8 Gy), respectively. Conclusion Target volume coverage still has to be prioritized over organs at risk (OAR) sparing with new RT techniques. Submandibular glands are not sufficiently taken into account in guidelines. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1028–1034, 2016
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.24398