Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats

• Published in: Phytotherapy research 2016-07, Vol.30 (7), p.1156-1163
• Main Authors: Akinyemi, Ayodele Jacob, Thomé, Gustavo Roberto, Morsch, Vera Maria, Bottari, Nathieli B., Baldissarelli, Jucimara, de Oliveira, Lizielle Souza, Goularte, Jeferson Ferraz, Belló-Klein, Adriane, Oboh, Ganiyu, Schetinger, Maria Rosa Chitolina
• Format: Article
• Language: English
• Subjects: ADA; Adenosine Deaminase - metabolism; Adenosine Triphosphatases - metabolism; Animals; Blood Platelets - drug effects; Blood Platelets - enzymology; Blood Pressure - drug effects; Curcuma; Curcuma longa; Dietary Supplements; ectonucleotidases; hypertension; Hypertension - drug therapy; Hypertension - enzymology; Male; NG-Nitroarginine Methyl Ester - pharmacology; Phytotherapy; platelet; Rats; Rats, Wistar; Rhizome; Zingiber officinale
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.5621

Hypertension is associated with platelet alterations that could contribute to the development of cardiovascular complications. Several studies have reported antiplatelet aggregation properties of ginger (Zingiber officinale) and turmeric (Curcuma longa) with limited scientific basis. Hence, this study assessed the effect of dietary supplementation of these rhizomes on platelet ectonucleotidase and adenosine deaminase (ADA) activities in Nω‐nitro‐l‐arginine methyl ester hydrochloride (l‐NAME) induced hypertensive rats. Animals were divided into seven groups (n = 10): normotensive control rats; induced (l‐NAME hypertensive) rats; hypertensive rats treated with atenolol (10 mg/kg/day); normotensive and hypertensive rats treated with 4% supplementation of turmeric or ginger, respectively. After 14 days of pre‐treatment, the animals were induced with hypertension by oral administration of l‐NAME (40 mg/kg/day). The results revealed a significant (p