The Relationship Between Neutrophil-to-Lymphocyte Ratio and Coronary Collateral Circulation

Neutrophil/lymphocyte ratio (NLR) has been proposed as a prognostic marker to determine systemic inflammatory response and atherosclerosis. Our aim was to determine the relationship between NLR and development of coronary collateral circulation (CCC) in patients with stable coronary artery disease (...

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Published in:Clinical and applied thrombosis/hemostasis 2015-05, Vol.21 (4), p.329-333
Main Authors: Uysal, Onur Kadir, Turkoglu, Caner, Sahin, Durmus Yildiray, Duran, Mustafa, Yıldırım, Arafat, Elbasan, Zafer, Ozkan, Bugra, Tekin, Kamuran, Kunak, Aysegul Ulgen, Yilmaz, Yucel, Kaya, Mehmet Gungor, Gur, Mustafa, Cayli, Murat
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis
Blood
Blood Glucose - metabolism
Cardiovascular disease
Coronary Artery Disease - blood
Coronary Artery Disease - physiopathology
Coronary Circulation
Coronary Vessels - physiopathology
Fasting - blood
Female
Humans
Lymphocyte Count
Lymphocytes
Male
Middle Aged
Neutrophils
Predictive Value of Tests
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Summary:Neutrophil/lymphocyte ratio (NLR) has been proposed as a prognostic marker to determine systemic inflammatory response and atherosclerosis. Our aim was to determine the relationship between NLR and development of coronary collateral circulation (CCC) in patients with stable coronary artery disease (CAD). A total of 521 consecutive patients with stable CAD who underwent coronary angiography and documented total occlusion in one of those major coronary arteries were included in this study. Levels of fasting blood glucose, white blood cell, and NLR were significantly higher in patients with poor collateral than in those with good collateral. After multivariate analysis, high level of NLR was an independent predictor of CCC together with levels of fasting blood glucose. The receiver–operating characteristic analysis provided a cutoff value of 2.75 for NLR to predict poor CCC with 65% sensitivity and 68% specificity. We demonstrated an independent association between levels of NLR and development of CCC in patients with stable CAD.
ISSN:1076-0296
1938-2723
DOI:10.1177/1076029613503399