Production and physico-chemical characterization of nanocapsules of the essential oil from Lippia sidoides Cham

[Display omitted] •Lippia sidoides essential oil was nanoencapsulated by the emulsion-diffusion method.•Nanoformulations were characterized by NMR, TGA, DSC and SEM.•Polycaprolactone-coated nanocapsules were stable at 5°C for 60 days. Lippia sidoides (Verbenaceae) is a medicinal plant from Northeast...

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Published in:Industrial crops and products 2016-08, Vol.86, p.279-288
Main Authors: Pinto, Náyra de Oliveira Frederico, Rodrigues, Tigressa Helena Soares, Pereira, Rita de Cássia Alves, Silva, Lorena Mara Alexandre e, Cáceres, Carlos Alberto, Azeredo, Henriette Monteiro Cordeiro de, Muniz, Celli Rodrigues, Brito, Edy Sousa de, Canuto, Kirley Marques
Format: Article
Language:English
Subjects:
DOSY-NMR
Essential oil
Lippia
Lippia sidoides
Nanocapsules
Polycaprolactone
Thymol
Verbenaceae
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Summary:[Display omitted] •Lippia sidoides essential oil was nanoencapsulated by the emulsion-diffusion method.•Nanoformulations were characterized by NMR, TGA, DSC and SEM.•Polycaprolactone-coated nanocapsules were stable at 5°C for 60 days. Lippia sidoides (Verbenaceae) is a medicinal plant from Northeastern Brazil, whose essential oil is rich in thymol, being a well-known antimicrobial phenol compound. The aim of this study was to produce suspensions of polycaprolactone (PCL)-coated nanocapsules incorporated with the essential oil from the L. sidoides leaves (EOLS) by the emulsion-diffusion method. EOLS nanocapsules were prepared by mixing EOLS and PCL with Kolliphor P 188® as the surfactant and ethyl laurate (core oil), all of them in varying concentrations (1, 2.5 and 5%). The said nanoformulations were assessed for their particle size and encapsulation efficiency (EE). The best condition was achieved with the nanoformulation containing 1% Kolliphor P 188®, 2.5% polycaprolactone, 2.5% EOLS and 5% ethyl laurate, emulsified at 10,000rpm for 5min, which presented an average particle diameter with 173.6nm, a polydispersity index of 0.2 and an EE of 70.6%. Additionally, the nanoemulsion was characterized by the nuclear magnetic resonance (1H and diffusion-ordered NMR spectroscopy- DOSY), scanning electron microscopy, thermogravimetry and the differential scanning calorimetry. Furthermore, the suspension of nanocapsules of the EOLS was demonstrated to be stable at 5°C during 60days of storage in an accelerated stability study.
ISSN:0926-6690
1872-633X
DOI:10.1016/j.indcrop.2016.04.013