A Possible Case of Hepatitis due to Hypereosinophilic Syndrome

• Published in: Internal Medicine 2016/06/01, Vol.55(11), pp.1453-1458
• Main Authors: Kawamura, Tomoe, Hiraoka, Atsushi, Toshimori, Akiko, Ueki, Hidetaro, Kaneto, Miho, Aibiki, Toshihiko, Okudaira, Tomonari, Yamago, Hiroka, Nakahara, Hiromasa, Tomida, Hideomi, Suga, Yoshifumi, Azemoto, Nobuaki, Mori, Kenichiro, Miyata, Hideki, Ninomiya, Tomoyuki, Hirooka, Masashi, Abe, Masanori, Matsuura, Bunzo, Hiasa, Yoichi, Kito, Katsumi, Michitaka, Kojiro
• Format: Article
• Language: English
• Subjects: acute hepatitis; Adrenal Cortex Hormones - therapeutic use; Biopsy; eosinophilia; eosinophilic hepatitis; Hepatitis - complications; Hepatitis - diagnosis; Hepatitis - drug therapy; Humans; hypereosinophilic syndrome; Hypereosinophilic Syndrome - complications; Hypereosinophilic Syndrome - diagnosis; Hypereosinophilic Syndrome - drug therapy; Leukocyte Count; Male; Middle Aged; Tomography, X-Ray Computed
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.55.5982

A 63-year-old Japanese man whose white blood cell count and total-bilirubin and aminotransferase levels were elevated was referred to our hospital. Computed tomography did not reveal any abnormalities, and there was no evidence of gastritis or colitis on esophagogastroduodenoscopy. Although the patient had no history of drug use or allergies, a high concentration of eosinophils (80%) was noted. A liver biopsy revealed hepatitis with eosinophilic infiltration. The patient's alanine aminotransferase and eosinophil levels improved with the administration of steroids. A second biopsy, performed 6 months later, showed the improvement of the eosinophilic infiltration. The patient was diagnosed with eosinophilic hepatitis due to the presence of hypereosinophilic syndrome without the dysfunction of other organs.