Effects of ADH1B and ALDH2 Genetic Polymorphisms on Alcohol Elimination Rates and Salivary Acetaldehyde Levels in Intoxicated Japanese Alcoholic Men

• Published in: Alcoholism, clinical and experimental research clinical and experimental research, 2016-06, Vol.40 (6), p.1241-1250
• Main Authors: Yokoyama, Akira, Kamada, Yoko, Imazeki, Hiromi, Hayashi, Emiko, Murata, Shigenori, Kinoshita, Kenji, Yokoyama, Tetsuji, Kitagawa, Yoshinori
• Format: Article
• Language: English
• Subjects: Acetaldehyde; Acetaldehyde - metabolism; Alcohol; Alcohol Dehydrogenase; Alcohol Dehydrogenase - genetics; Alcoholic Intoxication - genetics; Alcoholic Intoxication - metabolism; Alcoholism; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial - genetics; Asian Continental Ancestry Group - genetics; Dehydrogenases; Ethanol - metabolism; Ethanol Elimination; Genetic Predisposition to Disease - genetics; Genotype; Humans; Male; Polymorphism, Genetic; Regression analysis; Saliva; Saliva - metabolism
• ISSN: 0145-6008; 1530-0277
• DOI: 10.1111/acer.13073

Background The genetic polymorphisms of alcohol dehydrogenase‐1B (ADH1B) and aldehyde dehydrogenase‐2 (ALDH2) are associated with the risk of alcoholism and upper aerodigestive tract cancer in alcoholics. Salivary ethanol (sEtOH) levels are well correlated with blood EtOH levels. Methods To study the effects of ADH1B and ALDH2 genotypes on the alcohol elimination rate (AER) and salivary acetaldehyde (sAcH) levels, we measured the sEtOH and sAcH levels twice at a 1‐hour intervals in 99 intoxicated Japanese alcoholic men who had stopped drinking for 4 or more hours. Results The initial sEtOH levels did not differ between the ADH1B*2 group (n = 50) and the ADH1B*1/*1 group (n = 49) (median: 0.617 vs. 0.762 mg/ml). The salivary AER (sAER) increased as the sEtOH levels increased (p