Inhibitory effects of heterotopic noxious counter-stimulation on perception and brain activity related to Aβ-fibre activation

• Published in: The European journal of neuroscience 2016-07, Vol.44 (1), p.1771-1778
• Main Authors: Rustamov, Nabi, Tessier, Jessica, Provencher, Benjamin, Lehmann, Alexandre, Piché, Mathieu
• Format: Article
• Language: English
• Subjects: Adult; Brain - physiology; brain activity; CPM; Diffuse Noxious Inhibitory Control - physiology; DNIC; Evoked Potentials, Somatosensory; Female; human; Humans; Male; Nerve Fibers - physiology; Nociceptive Pain - physiopathology; pain; Pain Perception; tactile
• ISSN: 0953-816X; 1460-9568
• DOI: 10.1111/ejn.13258

Heterotopic noxious counter‐stimulation (HNCS) inhibits pain and pain processes through cerebral and cerebrospinal mechanisms. However, it is unclear whether HNCS inhibits non‐nociceptive processes, which needs to be clarified for a better understanding of HNCS analgesia. The aim of this study was to examine the effects of HNCS on perception and scalp somatosensory evoked potentials (SEPs). Seventeen healthy volunteers participated in two counter‐balanced sessions, including non‐nociceptive (selective Aβ‐fibre activation) or nociceptive electrical stimulation, combined with HNCS. HNCS was produced by a 20‐min cold pressor test (left hand) adjusted individually to produce moderate pain (mean ± SEM: 42.5 ± 5.3 on a 0–100 scale, where 0 is no pain and 100 the worst pain imaginable). Non‐nociceptive electrical stimulation was adjusted individually at 80% of pain threshold and produced a tactile sensation in every subject. Nociceptive electrical stimulation was adjusted individually at 120% of RIII‐reflex threshold and produced moderate pain (45.3 ± 4.5). Shock sensation was significantly decreased by HNCS compared with baseline for non‐nociceptive (P