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Iodine(III)-Mediated Selective Intermolecular C–H Amination for the Chemical Diversification of Tryptamines
Defined hypervalent iodine reagents of the general structure PhI[N(SO2R)(SO2R′)]2 promote the selective direct C–H-amination of the indole core of various tryptamines. Starting from a general C2-amination strategy, subsequent transformations enable a variety of site-selective functionalizations,...
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Published in: | Journal of organic chemistry 2016-08, Vol.81 (15), p.6496-6504 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Defined hypervalent iodine reagents of the general structure PhI[N(SO2R)(SO2R′)]2 promote the selective direct C–H-amination of the indole core of various tryptamines. Starting from a general C2-amination strategy, subsequent transformations enable a variety of site-selective functionalizations, which proceed with noteworthy high chemoselectivity and provide an overall access to structurally diversified products. |
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ISSN: | 0022-3263 1520-6904 |
DOI: | 10.1021/acs.joc.6b01118 |