Psychotropic drugs and risk of burn injury in individuals with mental illness: a 10-year population-based case-control study

• Published in: Pharmacoepidemiology and drug safety 2016-08, Vol.25 (8), p.918-927
• Main Authors: Chang, Chia-Ming, Wu, Kuan-Yi, Chiu, Yu-Wen, Wu, Hsiao-Ting, Tsai, Yu-Ting, Chau, Yeuk-Lun, Tsai, Hui-Ju
• Format: Article
• Language: English
• Subjects: Adult; burn injury; Burns; Burns - epidemiology; Case-Control Studies; Databases, Factual; Female; Humans; Logistic Models; Male; Mental Disorders - drug therapy; mental illness; Middle Aged; pharmacoepidemiology; Psychopharmacology; Psychotropic drugs; Psychotropic Drugs - administration & dosage; Psychotropic Drugs - adverse effects; Risk; Side effects; Taiwan - epidemiology; Young Adult
• ISSN: 1053-8569; 1099-1557
• DOI: 10.1002/pds.3995

Purpose We aimed to investigate the association between psychotropic treatment and risk of burn injury in individuals with mental illness. Methods A nested case–control study was conducted by using the National Health Insurance Research Database in Taiwan. A total of 3187 cases with burn injury under International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM) codes 940–949 and 19 122 matched controls were identified from 2003 to 2012. Four kinds of psychotropic agents (antipsychotics (APs), antidepressants (ADs), benzodiazepines, and z‐drugs) were examined. Psychotropic exposure status was measured, and a set of potential confounding factors was adjusted in the analyses. Conditional logistic regressions were applied to determine the effect of psychotropic use on burn injury. Results A significant increased risk of burn injury was observed among psychotropic users compared with non‐users (adjusted odds ratio (AOR) = 1.45, 95%CI = 1.31–1.61). When classifying psychotropic users into current, new, continuous, and past users, a significant elevated risk of burn injury was found across all groups (AOR = 1.76, 95%CI = 1.54–2.00 in current users; AOR = 2.02, 95%CI = 1.55–2.65 in new users; AOR = 1.72, 95%CI = 1.50–1.96 in continuous users; and AOR = 1.35, 95%CI = 1.21–1.51 in past users). When assessing each individual kind of examined psychotropic agents, a significant elevated risk of burn injury was found among users of APs, ADs, benzodiazepines, and z‐drugs except for current and continuous users of z‐drugs. Conclusions The results demonstrate an elevated risk of burn injury among individuals with current psychotropic use. The findings underscore the need for greater attention to be given to the cognitive performance and psychomotor abilities of individuals taking psychotropic medications in order to prevent the occurrence of burn injury. Copyright © 2016 John Wiley & Sons, Ltd.